Skip to main content

Advertisement

SpringerLink
Log in

18F-FDG-avid sites mimicking active disease in pediatric Hodgkin’s

  • Pictorial Essay
  • Published:
Pediatric Radiology Aims and scope Submit manuscript

Abstract

About 1,700 children in the United States are diagnosed yearly with lymphomas; Hodgkin’s disease accounts for approximately half of these cases, or 6% of all childhood cancers. Contemporary therapy allows for the achievement of remission in the majority of cases. The fusion of positron emission tomography (PET) with CT provides the most accurate imaging method for disease characterization and treatment response. However, experience with 18F-FDG PET-CT is limited in pediatric Hodgkin’s disease. Numerous non-oncologic processes can mimic recurrent or residual tumor. This pictorial addresses mimickers of disease such as uptake in normal structures, infections, transforming germinal canters and effects of therapy on normal tissues. It is essential for radiologists to be familiar with these findings in order to stage disease activity and therapeutic response accurately.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10
Fig. 11
Fig. 12

Similar content being viewed by others

References

  1. Hudson MM, Krasin MJ, Kaste SC (2004) PET imaging in pediatric Hodgkin’s lymphoma. Pediatr Radiol 34:190–198

    Google Scholar 

  2. Weiner M, Leventhal B, Cantor A, et al (1991) Gallium-67 scans as an adjunct to computed tomography scans for the assessment of a residual mediastinal mass in pediatric patients with Hodgkin’s disease. A pediatric oncology group study. Cancer 68:2478–2480

    CAS  PubMed  Google Scholar 

  3. Kostakoglu L, Agress H, Goldsmith SJ (2003) Clinical role of FDG PET in evaluation of cancer patients. Radiographics 23:315–340

    PubMed  Google Scholar 

  4. Hudson MM (2002) Pediatric Hodgkin’s therapy: time for a paradigm shift. J Clin Oncol 20:3755–3757

    PubMed  Google Scholar 

  5. Krasin MJ, Hudson MM, Kaste SC (2004) Positron emission tomography in pediatric radiation oncology: integration in the treatment planning process. Pediatr Radiol 34:214–221

    Article  PubMed  Google Scholar 

  6. Barrington SF, O‘Doherty MJ (2003) Limitations of PET for imaging lymphoma. Eur J Nucl Med Mol Imaging 30(Suppl 1):S117–S127

    Article  PubMed  Google Scholar 

  7. Wahl RL (2002) Principles and practice of positron emission tomography. Lippincott Williams and Wilkins, pp 111–136

    Google Scholar 

  8. Lerman H, Metser U, Grisaru D, et al (2004) Normal and abnormal 18F-FDG endometrial and ovarian uptake in pre- and post-menopausal patients: assessment by PET/CT. J Nucl Med 45:266–271

    PubMed  Google Scholar 

  9. Frush DP (2001) Imaging evaluation of the thymus and thymic disorders in children. In: Strife JL, Lucaya J (eds) Pediatric chest imaging: chest imaging in infants and children. Springer, Berlin Heidelberg New York, pp 187–208

    Google Scholar 

  10. Fletcher BD, Kauffman WM, Kaste SC, et al (1995) Use of thallium-201 to detect untreated pediatric Hodgkin’s disease. Radiology 196:851–855

    CAS  PubMed  Google Scholar 

  11. Fletcher BD, Xiong X, Kauffman WM, et al (1998) Hodgkin’s disease: use of Tl-201 to monitor mediastinal involvement after treatment. Radiology 209:471–475

    CAS  PubMed  Google Scholar 

  12. Kaste SC (2001) Lymphoma: controversies in imaging the chest. In: Strife JL, Lucaya J (eds) Pediatric chest imaging: chest imaging in infants and children. Springer, Berlin Heidelberg New York, pp 209–223

    Google Scholar 

  13. Barrington S, Maisey M (1996) Skeletal muscle uptake of fluorine-18-FDG: effect of oral diazepam. J Nucl Med 37:1127–1129

    CAS  PubMed  Google Scholar 

  14. Yeung HW, Grewal RK, Gonen M, et al (2003) Patterns of (18)F-FDG uptake in adipose tissue and muscle: a potential source of false-positives for PET. J Nucl Med 44:1789–1796

    PubMed  Google Scholar 

  15. Hollingshead LM, Goa XL (1991) Recombinant granulocyte colony-stimulating factor (rG-CSF). A review of its pharmacological properties and prospective role in neutropenic conditions. Drugs 42:300–330

    CAS  PubMed  Google Scholar 

  16. Sugawara Y, Fisher SJ, Zasadny KR, et al (1998) Preclinical and clinical studies of bone marrow uptake of fluorine-1-fluorodeoxyglucose with or without granulocyte colony-stimulating factor during chemotherapy. J Clin Oncol 16:173–180

    CAS  PubMed  Google Scholar 

  17. Kaste SC (2004) Issues specific to implementing PET-CT for pediatric oncology: what we have learned along the way. Pediatr Radiol 34:205–213

    Article  PubMed  Google Scholar 

  18. Tomas MB, Tronco GG, Karayalcin G, et al (2000) FDG uptake in infectious mononucleosis. Clin Positron Imaging 3:176

    Article  PubMed  Google Scholar 

  19. Hara T, Kosaka N, Suzuki T, et al (2003) Uptake rates of 18F-fluorodeoxyglucose and 11C-choline in lung cancer and pulmonary tuberculosis: a positron emission tomography study. Chest 124:893–901

    Article  CAS  PubMed  Google Scholar 

  20. Goerres GW, von Schulthess GK, Hany TF (2002) Positron emission tomography and PET CT of the head and neck: FDG uptake in normal anatomy, in benign lesions, and in changes resulting from treatment. AJR 179:1337–1343

    PubMed  Google Scholar 

  21. Hansmann ML, Fellbaum C, Hui PK, et al (1990) Progressive transformation of germinal centers with and without association to Hodgkin’s disease. Am J Clin Pathol 93:219–226

    CAS  PubMed  Google Scholar 

Download references

Acknowledgements

Supported in part by grants P30 CA-21765 and P01 CA-20180 from the National Cancer Institute, a Center of Excellence grant from the State of Tennessee from the National Institutes of Health, and by the American Lebanese Syrian Associated Charities (ALSAC).

Author information

Authors and Affiliations

  1. St. Jude Children’s Research Hospital, Departments of Radiological Sciences and Hematology-Oncology, Department of Radiology, University of Tennessee College of Medicine, 332 N. Lauderdale, Memphis, TN, 38105, USA

    Sue C. Kaste

  2. Hematology-Oncology Department, St. Jude Children’s Research Hospital, Memphis, TN, USA

    Scott C. Howard & Melissa M. Hudson

  3. Radiological Sciences, St. Jude Children’s Research Hospital, Memphis, TN, USA

    Elizabeth B. McCarville & Matthew J. Krasin

  4. St. Jude Children’s Research Hospital, Radiological Sciences, Department of Radiology, University of Tennessee College of Medicine, Memphis, TN, USA

    Philip G. Kogos

Authors
  1. Sue C. Kaste
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Scott C. Howard
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Elizabeth B. McCarville
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Matthew J. Krasin
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Philip G. Kogos
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Melissa M. Hudson
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sue C. Kaste.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kaste, S.C., Howard, S.C., McCarville, E.B. et al. 18F-FDG-avid sites mimicking active disease in pediatric Hodgkin’s. Pediatr Radiol 35, 141–154 (2005). https://doi.org/10.1007/s00247-004-1340-3

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00247-004-1340-3

Keywords

Search

Navigation