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Blood flow parameters of the superior mesenteric artery as an early predictor of intestinal dysmotility in preterm infants

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Abstract

Background

Blood flow parameters in the superior mesenteric artery (SMA) change with vasoconstriction or vasodilatation of the intestinal vascular bed. In cases of severe growth retardation as a result of haemodynamic disturbances, the blood flow changes persist into postnatal life.

Objective

To assess early changes of Doppler sonographic blood flow parameters in the SMA for prediction of later intestinal motility disturbances in preterm infants and tolerance of enteral feeding during the first week of life.

Materials and methods

Doppler sonographic blood flow parameters in the SMA were measured on the first day of life and the following 5 days in 478 neonates with a birth weight below 1,500 g. According to the Doppler results, the neonates were divided into two groups—those with pathological parameters and those with normal blood flow parameters. Correlations between blood flow parameters, the development of intestinal dysmotility and the tolerated amount of enteral feeding were calculated.

Results

Pathological blood flow parameters were observed in 148 neonates (group 1) and normal blood flow parameters in 330 neonates (group 2). Intestinal motility disturbance occurred in 125 neonates (83%) of group 1 and 47 neonates (15%) of group 2. Neonates in group 2 tolerated significantly more feed by the fifth day of life than neonates in group 1. Postnatal adaptation did not differ between the two groups, although the majority of neonates with intestinal dysmotility were small for gestational age. The predictive value of blood flow parameters for prediction of intestinal motility revealed high sensitivity and specificity by the first postnatal day, 2 or 3 days before development of clinical signs of intestinal dysmotility. There was a strong negative correlation between pathological pulsatility index on day 1 and the quantity of tolerated enteral feeding on day 5.

Conclusions

Pathological blood flow parameters in the SMA can predict problems of intestinal motility and tolerance of enteral feeding. With the early detection of these problems a prompt start of adequate therapy to avoid complications is possible.

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Authors and Affiliations

  1. Department of Neonatology, Children’s Hospital, University of Leipzig, Oststrasse 21–25, 04317, Leipzig, Germany

    Eva Robel-Tillig, Matthias Knüpfer, Ferdinand Pulzer & Christoph Vogtmann

Authors
  1. Eva Robel-Tillig
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  2. Matthias Knüpfer
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  3. Ferdinand Pulzer
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  4. Christoph Vogtmann
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Correspondence to Eva Robel-Tillig.

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Robel-Tillig, E., Knüpfer, M., Pulzer, F. et al. Blood flow parameters of the superior mesenteric artery as an early predictor of intestinal dysmotility in preterm infants. Pediatr Radiol 34, 958–962 (2004). https://doi.org/10.1007/s00247-004-1285-6

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  • DOI: https://doi.org/10.1007/s00247-004-1285-6

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