Abstract
Growing teratoma syndrome is defined as enlarging masses of mature teratoma following chemotherapy for malignant nonseminomatous germ-cell tumors. Typically, there is associated normalization of initially elevated serum tumor markers. We describe clinical and imaging findings in a case of growing teratoma syndrome originating from immature teratoma of the ovary in a 12-year-old girl. Familiarity with this unusual entity is important to avoid confusion with advancing malignancy.
Similar content being viewed by others
References
Logothetis CJ, Samuels M, Trindade A, et al (1982) The growing teratoma syndrome. Cancer 50:1629–1635
Caldas C, Sitzman J, Trimble CL, et al (1992) Synchronous mature teratomas of the ovary and liver: a case presenting 11 years following chemotherapy for immature teratoma. Gynecol Oncol 47:385–390
Andre F, Fizazi K, Culine S, et al (2000) The growing teratoma syndrome: results of therapy and long term follow-up of 33 patients. Eur J Cancer 36:1389–1394
Afifi HY, Bosl GJ, Burt ME (1997) Mediastinal growing teratoma syndrome. Ann Thorac Surg 64:359–362
O’Callaghan AM, Katapodis O, Ellison DW, et al (1997) The growing teratoma syndrome in a nongerminomatous germ cell tumor of the pineal gland: a case report and review. Cancer 80:942–947
Ravi R (1995) Growing teratoma syndrome. Urol Int 55:226–228
Labdenne P, Heikinheimo M (2002) Clinical use of tumor markers in childhood malignancies. Ann Med 34:316–323
Bast RC Jr (2003) Status of tumor markers in ovarian cancer screening. J Clin Oncol 21(10S):200–205
Moskovic E, Jobling T, Fisher C, et al (1991) Retroconversion of immature teratoma of the ovary: CT appearances. Clin Radiol 43:402–408
Outwater EK, Siegelman ES, Hunt JL (2001) Ovarian teratomas: tumor types and imaging characteristics. Radiographics 21:475–490
Itani Y, Kawa M, Toyoda S, et al (2002) Growing teratoma syndrome after chemotherapy for a mixed germ cell tumor of the ovary. J Obstet Gynaecol Res 28:166–171
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Nimkin, K., Gupta, P., McCauley, R. et al. The growing teratoma syndrome. Pediatr Radiol 34, 259–262 (2004). https://doi.org/10.1007/s00247-003-1045-z
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00247-003-1045-z