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Longitudinal Deformation of the Right Ventricle in Hypoplastic Left Heart Syndrome: A Comparative Study of 2D-Feature Tracking Magnetic Resonance Imaging and 2D-Speckle Tracking Echocardiography

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Abstract

In hypoplastic left heart syndrome (HLHS), long-term outcome is closely related to right ventricular function. Echocardiography and magnetic resonance imaging (MRI) are routinely used for functional assessment. MRI 2D-tissue feature tracking (2D-FT) allows quantification of myocardial deformation but has not yet been applied to HLHS patients. We sought to investigate the feasibility of this technique and to compare the results to 2D-speckle tracking echocardiography (2D-STE). In routine MRI 2D anatomical four chamber view, cine images were recorded in 55 HLHS patients (median age 4.9 years [1.6, 17.0]). Regional and global peak systolic longitudinal strain (LS) and strain rate (LSR) were determined using 2D-FT software. Echocardiographic four chamber view was analyzed with 2D-STE. Visualization of all myocardial segments with MRI was excellent, regional, and global LS and LSR could be assessed in all data sets. In 2D-STE, 28% of apical segments could not be analyzed due to poor image quality. Agreement of 2D-FT MRI and 2D-STE was acceptable for global LS, but poor for global LSR. In MRI, regional LS was lower in the septal segments, while LSR was not different between the segments. GLS and GLSR correlated with ejection fraction (GLS: r = − 0.45 and r < 0.001, GLSR: r = − 0.34 and p = 0.01). With new post-processing options, the assessment of regional and global LS and LSR is feasible in routine MRI of HLHS patients. For LS, results were comparable with 2D-STE. The agreement was poor for LSR, which might relate to differences in temporal resolution between the two imaging modalities.

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Acknowledgements

The authors thank Mrs. Traudel Hansen and Mrs. Gabriele Kroeger for their assistance in patient management, Dr. Marka-Jill Jussli-Melchers and Dr. Jens Groebner for clinical and technical comments.

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Authors and Affiliations

  1. Department of Congenital Heart Disease and Pediatric Cardiology, University Hospital Schleswig-Holstein (UKSH), Campus Kiel, Arnold-Heller-Street 3, Building 9, 24105, Kiel, Germany

    Mona Salehi Ravesh, Carsten Rickers, Finn Jonathan Bannert, Abdullah Al Bulushi, Dominik Daniel Gabbert, Philip Wegner, Eva Kis, Jan Hinnerk Hansen, H.-H. Kramer & Jana Logoteta

  2. Medis Medical Imaging Systems BV, Leiden, The Netherlands

    David Hautemann

  3. Department of Pediatric Cardiology, National Heart Centre, Royal Hospital, Muscat, Oman

    Abdullah Al Bulushi

  4. Hungarian Institute of Cardiology, Pediatric Heart Centre, Budapest, Hungary

    Eva Kis

  5. Department of Radiology, Brigham & Women’s Hospital, Boston, MA, USA

    Michaeal Jerosch-Herold

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  1. Mona Salehi Ravesh
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  2. Carsten Rickers
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  3. Finn Jonathan Bannert
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  5. Abdullah Al Bulushi
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  11. H.-H. Kramer
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  12. Jana Logoteta
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Correspondence to Mona Salehi Ravesh.

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The authors declare that they have no conflict of interest.

Ethical Approval

The study was performed according to the protocol (No. AZ 168/07) approved by the institutional ethics committee and in accordance with the ethical standards laid down in the 1964 declaration of Helsinki and its later amendments.

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All parents or legal guardians gave their informed consent in a written form.

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Salehi Ravesh, M., Rickers, C., Bannert, F. et al. Longitudinal Deformation of the Right Ventricle in Hypoplastic Left Heart Syndrome: A Comparative Study of 2D-Feature Tracking Magnetic Resonance Imaging and 2D-Speckle Tracking Echocardiography. Pediatr Cardiol 39, 1265–1275 (2018). https://doi.org/10.1007/s00246-018-1892-x

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  • DOI: https://doi.org/10.1007/s00246-018-1892-x

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