Abstract
The objective of this study was to measure intima–media thickness (IMT) of the abdominal aortic (aIMT) and common carotid (cIMT) arteries in normal term newborns. We measured aIMT and cIMT using high-resolution ultrasonography in 100 normal term newborns during the first 4 days of life. Mean abdominal aIMT and cIMT values of term newborns were 0.51 ± 0.041 mm (n = 100) and 0.37 ± 0.054 mm (n = 100), respectively. Maximum and minimum aIMT and cIMT values of term newborns were 0.58 and 0.42 mm and 0.47 and 0.32 mm, respectively. The intraobserver intrasubject correlation coefficients for aIMT, right cIMT, and left cIMT were 0.89, 0.91, and 0.92, respectively (coefficient of variation = 5 %). The study provides data for normal aIMT and cIMT values in normal term newborns. By establishing normal values, we can further study the aetiopathogenesis of various possible intrauterine risk factors in premature atherosclerosis in normal or intrauterine growth–retarded newborns.
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References
Barker DJ, Winter PD, Osmond C, Margetts B, Simmonds SJ (1989) Weight in infancy and death from ischemic disease. Lancet 2:577–580
Bots ML, Hoes AW, Koudstaal PJ et al (1997) Common carotid intima-media thickness and risk of stroke and myocardial infarction: The Rotterdam Study. Circulation 96:1432–1437
Gordon T, Kannel WB (1971) Premature mortality from coronary heart disease: the Framingham Study. JAMA 215(10):1617–1625
Hoskote SS, Joshi SR (2008) Carotid intimomedial thickness—a non-invasive index of vascular health. J Assoc Physicians India 56:577–578
Koklu E, Kurtoglu S, Akcakus M et al (2006) Increased aortic intima-media thickness is related to lipid profile in newborns with intrauterine growth restriction. Horm Res 65:269–275
Libby P (2008) The pathogenesis, prevention and treatment of atherosclerosis. In: Fauci AS, Brawnwald E, Kasper D, Hauser SL, Longo DL, Jameson JL et al (eds) Harrison’s principles of internal medicine, 17th edn. McGraw Hill, New York, p 4833
Lubchenco LC, Hansman C, Dresseler M et al (1963) Intrauterine growth as estimated from liveborn birth-weight data 24 to 42 weeks of gestation. Pediatrics 32:793–800
McGill HC, McMahan CA, Herderick EE et al (2000) Effects of coronary heart disease risk factors on atherosclerosis of selected regions of the aorta and right coronary artery: PDAY Research Group: Pathobiological determinants of atherosclerosis in youth. Arterioscler Thromb Vasc Biol 20:836–845
Raitakari OT (1999) Imaging of subclinical atherosclerosis in children and young adults. Ann Med 31:33–40
Salonen JT, Salonen R (1991) Ultrasonographically assessed carotid morphology and the risk of coronary heart disease. Arterioscler Thromb Vasc Biol 11:1245–1249
Skilton MR (2008) Intrauterine risk factors for precocious atherosclerosis. Pediatrics 121:570–574
Skilton MR, Evans N, Griffiths KA et al (2005) Aortic wall thickness in newborns with intrauterine growth restriction. Lancet 365:1484–1486
Sodhi KS, Sidhu R, Gulati M, Saxena A, Suri S, Chawla Y (2005) Role of tissue harmonic imaging in focal hepatic lesions: comparison with conventional sonography. J Gastroenterol Hepatol 20(10):1488–1493
Sodhi KS, Bartlett M, Prabhu NK (2011) Role of high resolution ultrasound in parotid lesions in children. Int J Pediatr Otorhinolaryngol 75(11):1353–1358
Stary HC (1989) Evolution and progression of atherosclerotic lesions in coronary arteries of children and young adults. Arteriosclerosis 9:19–32
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Hondappanavar, A., Sodhi, K.S., Dutta, S. et al. Quantitative Ultrasound Measurement of Intima–Media Thickness of Abdominal Aorta and Common Carotid Arteries in Normal Term Newborns. Pediatr Cardiol 34, 364–369 (2013). https://doi.org/10.1007/s00246-012-0464-8
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DOI: https://doi.org/10.1007/s00246-012-0464-8