Skip to main content

Advertisement

SpringerLink
Log in

An Infant Case of Dilated Cardiomyopathy Associated With Congenital Cytomegalovirus Infection

  • Case Report
  • Published:
Pediatric Cardiology Aims and scope Submit manuscript

Abstract

A 2-month-old infant with congestive heart failure was referred to the authors’ hospital. Echocardiography exhibited a dilated left ventricle (LV), poor LV systolic function, and intraventricular thrombus. Laboratory data showed a normal creatinine phosphokinase level and negative troponin T test results. The congestive heart failure was managed using a beta-blocker, an angiotensin receptor blocker, and diuretics. Head computed tomography performed during the treatment course showed periventricular calcifications. Congenital cytomegalovirus infection was subsequently diagnosed. Fetal echocardiography performed during pregnancy showed impaired LV function, suggesting that the cardiomyopathy was associated with cytomegalovirus infection in utero.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

References

  1. Bowles NE, Ni J, Kearney DL, Pauschinger M, Schultheiss HP, McCarthy R, Hare J, Bricker JT, Bowles KR, Towbin JA (2003) Detection of viruses in myocardial tissues by polymerase chain reaction: evidence of adenovirus as a common cause of myocarditis in children and adults. J Am Coll Cardiol 42:466–472

    Article  PubMed  Google Scholar 

  2. Dec GW Jr, Palacios IF, Fallon JT, Aretz HT, Mills J, Lee DC, Johnson RA (1985) Active myocarditis in the spectrum of acute dilated cardiomyopathies: clinical features, histologic correlates, and clinical outcome. N Engl J Med 312:885–890

    Article  PubMed  Google Scholar 

  3. Kytö V, Vuorinen T, Saukko P, Lautenschlager I, Lignitz E, Saraste A, Voipio-Pulkki LM (2005) Cytomegalovirus infection of the heart is common in patients with fatal myocarditis. Clin Infect Dis 40:683–688

    Article  PubMed  Google Scholar 

  4. O’Connell JB (1987) The role of myocarditis in end-stage dilated cardiomyopathy. Tex Heart Inst J 14:268–275

    PubMed  Google Scholar 

  5. Pass RF, Stagno S, Myers GJ, Alford CA (1980) Outcome of symptomatic congenital cytomegalovirus infection: results of long-term longitudinal follow-up. Pediatrics 66:758–762

    PubMed  CAS  Google Scholar 

  6. Weller TH (1971) The cytomegaloviruses: ubiquitous agents with protean clinical manifestations. N Engl J Med 285:203–214

    Article  PubMed  CAS  Google Scholar 

  7. Weller TH, Hanshaw JB (1962) Virologic and clinical observations on cytomegalic inclusion disease. N Engl J Med 266:1233–1244

    Article  PubMed  CAS  Google Scholar 

  8. Whitley RJ, Cloud G, Gruber W, Storch GA, Demmler GJ, Lacobs RF, Dankner W, Spector SA, Starr S, Pass RF, Stagno S, Britt WJ, Alford C Jr, Soong S, Zhou XJ, Sherrill L, FitzGerald JM, Sommadossi JP (1997) Ganciclovir treatment of symptomatic congenital cytomegalovirus infection: result of a phase II study. National Institute of Allergy and Infectious Disease Collaborative Antiviral Study Group. J Infect Dis 175:1080–1086

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatric Cardiology, National Cerebral and Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565, Japan

    Heima Sakaguchi, Tetsuya Yamamoto, Shin Ono, Akiko Akashi & Etsuko Tsuda

  2. Department of Pediatrics, Kitano Hospital, Osaka, Japan

    Ken Watanabe

Authors
  1. Heima Sakaguchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tetsuya Yamamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Shin Ono
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Akiko Akashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Etsuko Tsuda
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Ken Watanabe
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Heima Sakaguchi.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sakaguchi, H., Yamamoto, T., Ono, S. et al. An Infant Case of Dilated Cardiomyopathy Associated With Congenital Cytomegalovirus Infection. Pediatr Cardiol 33, 824–826 (2012). https://doi.org/10.1007/s00246-012-0212-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00246-012-0212-0

Keywords

Search

Navigation