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Epicardial Control of Myocardial Proliferation and Morphogenesis

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Abstract

The epicardium is a critical tissue that directs several aspects of heart development, particularly via the secretion of soluble factors. This review summarizes recent approaches that implicate the epicardium as the source of mitogenic factors promoting cardiomyocyte proliferation, as the source of instructive signals that direct compact zone organization (morphogenesis), and as the tissue that directs formation of the coronary vasculature.

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Acknowledgment

Research in the laboratory of H. M. Sucov described in this review was supported by NIH grant HL070123.

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  1. Institute for Genetic Medicine, University of Southern California Keck School of Medicine, 2250 Alcazar St., IGM240, Los Angeles, CA, 90033, USA

    Henry M. Sucov, Ying Gu, Simmy Thomas, Peng Li & Mohammad Pashmforoush

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  1. Henry M. Sucov
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  2. Ying Gu
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Correspondence to Henry M. Sucov.

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Sucov, H.M., Gu, Y., Thomas, S. et al. Epicardial Control of Myocardial Proliferation and Morphogenesis. Pediatr Cardiol 30, 617–625 (2009). https://doi.org/10.1007/s00246-009-9391-8

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