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Differences in Arterial Compliance Among Normotensive Adolescent Groups: Collins Arterial Compliance in Adolescents

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An Erratum to this article was published on 01 July 2008

An Erratum to this article was published on 01 July 2008

Abstract

Decreased arterial compliance is an important predictor of cardiovascular risk. Pulse wave velocity correlates well with arterial compliance. Gender and ethnic differences in adult populations have been described. However, few data are available evaluating arterial compliance in adolescent subjects. Using a simple noninvasive oscillometric technique, brachial–ankle pulse wave velocity (baPWV) was measured as an index of arterial stiffness. Measurements were performed on a cross-sectional (65% African American, 52% female) sample of 205 normotensive (blood pressure <95% for gender, height, and age) adolescents with a mean age of 15.9 years (range, 12–21 years). The 205 adolescent subjects include 106 females and 99 males. In these adolescents, the mean baPWV was higher for males (1,096 cm/s) than for females (1,039 cm/s; p < 0.0024; 95% confidence interval [CI], 0.2051–0.9349), and for African Americans (1,080 cm/s) than for whites (1,040 cm/s; p < 0.0438; 95% CI, 0.0112–0.7888). Multiple regression analyses found a three-way interaction among gender, ethnicity, and age. The effect of age on baPWV was greater among African Americans (slope = 18.1 cm/s/year) and males (slope = 21.6) than among whites (slope = 11.0) and females (slope = 11.3), although these differences did not reach statistical significance. Differences in arterial compliance are already present and detectable in normotensive adolescent subjects. Decreased arterial compliance among adolescent groups correlates with the known adult risk for cardiovascular events among the same ethnic and gender groups.

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Acknowledgments

The authors thank Kim Fisher, PhD, Nandor Kalli, MD, Sandy Grimes, RN, Andrew Nearn, and Ervin Coburn for their invaluable assistance. Also, Dr. Collins thanks Andrea Patters for her assistance with the manuscript. This research was supported in part by the Le Bonheur Children’s Medical Center Research Committee and The University of Tennessee Health Science Center, Memphis, TN, General Clinical Research Center grant M01 RR-00211 from the National Center for Research Resources, National Institutes of Health. Dr. Alpert has been a paid consultant for Colin Medical Instruments and Welch-Allyn Medical Instruments. The other authors have no conflicts of interest or disclosures to make known. The research represented in this manuscript was conducted at Le Bonheur Children’s Medical Center.

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Authors and Affiliations

  1. The Cardiac Center, 2nd Floor, Main Building, 34th Street and Civic Center Boulevard, Philadelphia, PA, 19104, USA

    R. Thomas Collins

  2. Department of Pediatrics, The University of Tennessee Health Science Center, Memphis, TN, USA

    R. Thomas Collins & Bruce S. Alpert

  3. Department of Internal Medicine, The University of Tennessee Health Science Center, Memphis, TN, USA

    R. Thomas Collins

  4. Department of Preventive Medicine, The University of Tennessee Health Science Center, Memphis, TN, USA

    Grant W. Somes

  5. Le Bonheur Children’s Medical Center, Memphis, TN, USA

    Bruce S. Alpert

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  1. R. Thomas Collins
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  2. Grant W. Somes
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Correspondence to R. Thomas Collins.

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An erratum to this article can be found at http://dx.doi.org/10.1007/s00246-008-9263-7

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Collins, R.T., Somes, G.W. & Alpert, B.S. Differences in Arterial Compliance Among Normotensive Adolescent Groups: Collins Arterial Compliance in Adolescents. Pediatr Cardiol 29, 929–934 (2008). https://doi.org/10.1007/s00246-008-9239-7

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