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Health-Related Quality of Life and Right Ventricular Function in the Midterm Follow-up Assessment After Tetralogy of Fallot Repair

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Abstract

Background

Few data are available on quality of life after surgical repair of tetralogy of Fallot (ToF), and on its relationship to right ventricle function.

Methods

Patients with at least 1 year of follow-up evaluation after surgery were studied. Right ventricle function was evaluated by the Doppler-derived myocardial performance index (MPI), and health-related quality of life (HRQL) was assessed by the Child Health Questionnaire, Parent Form-50. Findings were compared with those for an age- and sex-matched group of healthy children.

Results

The study enrolled 35 successfully repaired ToF patients with 4.9 years (range, 3–7 years) of follow-up evaluation after surgery and 36 healthy children. The MPI demonstrated right ventricle dysfunction in patients compared with controls (0.34; range, 0.26–0.49 vs 0.2; range, 0.13–0.27; p < 0.01), although HRQL for the psychosocial domain was similar between patients and healthy children (summary score, 47.9; range, 45–52 vs 47.5; range, 44.5–50; p = 0.17). A trend for poorer physical area results was observed in patients (summary score, 44; range, 31–52 vs 48.5; range, 45.7–51.7; p = 0.06). Neither physical nor psychosocial summary scores for HRQL had any correlation with right ventricle MPI.

Conclusions

Right ventricle dysfunction is present in postoperative ToF patients. The psychosocial domain of HRQL is preserved after surgery. A trend for worse results was observed in the physical domain. The right ventricle function is not related to quality of life after surgical repair of ToF.

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References

  1. Abd El Rahman MY, Abdul-Khaliq H, et al. (2002) Value of the new Doppler-derived myocardial performance index for the evaluation of right and left ventricular function following repair of tetralogy of Fallot. Pediatr Cardiol 23:502–507

    Article  PubMed  CAS  Google Scholar 

  2. Daliento L, Mapelli D, Russo G, et al. (2005) Health-related quality of life in adults with repaired tetralogy of Fallot: Psychosocial and cognitive outcomes. Heart 91:213–218

    Article  PubMed  CAS  Google Scholar 

  3. Davlouros PA, Kilner PJ, Hornung TS, et al. (2002) Right ventricular function in adults with repaired tetralogy of Fallot assessed with cardiovascular magnetic resonance imaging: Detrimental role of right ventricular outflow aneurysms or akinesia and adverse right-to-left ventricular interaction. J Am Coll Cardiol 40:2044–2052

    Article  PubMed  Google Scholar 

  4. Eidem BW, O’Leary PW, Tei C, Seward JB (2000) Usefulness of the myocardial performance index for assessing right ventricular function in congenital heart disease. Am J Cardiol 86:654–658

    Article  PubMed  CAS  Google Scholar 

  5. Eidem BW, Tei C, O’Leary PW, et al. (1998) Nongeometric quantitative assessment of right and left ventricular function: Myocardial performance index in normal children and patients with Ebstein anomaly. J Am Soc Echocardiogr 11:849–856

    Article  PubMed  CAS  Google Scholar 

  6. Freedom RM, Yoo SJ (2004) Tetralogy of Fallot. In: Freedom RM, Yoo SJ, Mikailian H, Williams WG (eds) The natural and modified history of congenital heart disease. 1st ed. Blackwell Publishing, New York, pp. 186–211

    Google Scholar 

  7. Frigiola A, Redington AN, Cullen S, Vogel M (2004) Pulmonary regurgitation is an important determinant of right ventricular contractile dysfunction in patients with surgically repaired tetralogy of Fallot. Circulation 110(11 Suppl):II-153–157

    Article  CAS  Google Scholar 

  8. Gatzoulis MA, Elliott JT, Guru V, et al. (2000) Right and left ventricular systolic function late after repair of tetralogy of Fallot. Am J Cardiol 86:1352–1357

    Article  PubMed  CAS  Google Scholar 

  9. Gatzoulis MA, Norgard G, Redington AN (1998) Biventricular long axis function after repair of tetralogy of Fallot. Pediatr Cardiol 19:128–132

    Article  PubMed  CAS  Google Scholar 

  10. Harada K, Tamura M, Toyono M, Yasuoka K (2002) Comparison of the right ventricular Tei index by tissue Doppler imaging to that obtained by pulsed Doppler in children without heart disease. Am J Cardiol 90:566–569

    Article  PubMed  Google Scholar 

  11. Ishii M, Eto G, Tei C, Tsutsumi T, et al. (2000) Quantitation of the global right ventricular function in children with normal heart and congenital heart disease: A right ventricular myocardial performance index. Pediatr Cardiol 21:416–421

    Article  PubMed  CAS  Google Scholar 

  12. LaCorte JC, Cabreriza SE, Rabkin DG, et al. (2003) Correlation of the Tei index with invasive measurements of ventricular function in a porcine model. J Am Soc Echocardiogr 16:442–447

    Article  PubMed  Google Scholar 

  13. Landgraf JM, Abetz L, Ware JE (1999) The CHQ user’s manual. 2nd printing. HealthAct, Boston

    Google Scholar 

  14. Murphy JG, Gersh BJ, Muir DD, et al. (1993) Long-term outcome in patients undergoing surgical repair of tetralogy of Fallot. N Engl J Med 329:593–599

    Article  PubMed  CAS  Google Scholar 

  15. Nollert G, Fischlein T, Bouterwek S, et al. (1997) Long-term survival in patients with repair of tetralogy of Fallot: Follow-up of 490 survivors of the first year after surgical repair. J Am Coll Cardiol 30:1374–1383

    Article  PubMed  CAS  Google Scholar 

  16. Norgaard MA, Lauridsen P, Helvind M, Petterson G (1999) Twenty- to thirty-seven-year follow-up after repair for tetralogy of Fallot. Eur J Cardiothorac Surg 16:125–30

    Article  PubMed  CAS  Google Scholar 

  17. Pigula FA, Khalil PN, Mayer JE, et al. (1999) Repair of tetralogy of Fallot in neonates and young infants. Circulation 100(19 Suppl):II-157–161

    CAS  Google Scholar 

  18. Roest AA, Helbing WA, Kunz P, et al. (2002) Exercise MR imaging in the assessment of pulmonary regurgitation and biventricular function in patients after tetralogy of Fallot repair. Radiology 223:204–211

    Article  PubMed  Google Scholar 

  19. Salehian O, Schwerzmann M, Merchant N, et al. (2004) Assessment of systemic right ventricular function in patients with transposition of the great arteries using the myocardial performance index: Comparison with cardiac magnetic resonance imaging. Circulation 110:3229–3233

    Article  PubMed  Google Scholar 

  20. Schamberger MS, Hurwitz RA (2000) Course of right and left ventricular function in patients with pulmonary insufficiency after repair of tetralogy of Fallot. Pediatr Cardiol 21:244–248

    Article  PubMed  CAS  Google Scholar 

  21. Singh GK, Greenberg SB, Yap YS, et al. (1998) Right ventricular function and exercise performance late after primary repair of tetralogy of Fallot with the transanular patch in infancy. Am J Cardiol 81:1378–1382

    Article  PubMed  CAS  Google Scholar 

  22. Tei C (1995) New noninvasive index for combined systolic and diastolic ventricular function. J Cardiol 26:135–136

    PubMed  CAS  Google Scholar 

  23. Tei C, Dujardin KS, Hodge DO, et al. (1996) Doppler echocardiographic index for assessment of global right ventricular function. J Am Soc Echocardiogr 9:838–347

    Article  PubMed  CAS  Google Scholar 

  24. Tei C, Nishimura RA, Seward JB, Tajik AJ (1997) Noninvasive Doppler-derived myocardial performance index: Correlation with simultaneous measurements of cardiac catheterization. J Am Soc Echocardiogr 10:169–178

    Article  PubMed  CAS  Google Scholar 

  25. Ternestedt BM, Wall K, Oddson H, et al. (2001) Quality of life 20 to 30 years after surgery in patients operated on for tetralogy of Fallot and for atrial septal defect. Pediatr Cardiol 22:128–132

    Article  PubMed  CAS  Google Scholar 

  26. Vogel M, Sponring J, Cullen S, et al. (2001) Regional wall motion and abnormalities of electrical depolarization and repolarization in patients after surgical repair of tetralogy of Fallot. Circulation 103:1669–1673

    PubMed  CAS  Google Scholar 

  27. Walker WT, Temple IK, Gnanapragasam JP, et al. (2002) Quality of life after repair of tetralogy of Fallot. Cardiol Young 12:549–553

    Article  PubMed  Google Scholar 

  28. Williams RV, Ritter S, Tani LY, et al. (2000) Quantitative assessment of ventricular function in children with single ventricles using the Doppler myocardial performance index. Am J Cardiol 86:1106–1110

    Article  PubMed  CAS  Google Scholar 

  29. Yasuoka K, Harada K, Toyono M, et al. (2004) Tei index determined by tissue Doppler imaging in patients with pulmonary regurgitation after repair of tetralogy of Fallot. Pediatr Cardiol 25:131–136

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Pediatric Cardiology, Intensive Care, and Cardiac Surgery Departments, Hospital da Criança Santo Antônio, Santa Casa de Porto Alegre, Av Independência, 155, 90035-074, Porto Alegre, RS, Brazil

    C. B. Pilla, C. A. Pereira, A. V. Fin, F. V. Aquino, A. Botta, L. DalleMulle, C. P. Ricachinevsky, A. J. Nogueira & F. A. Lucchese

  2. Cardiology Department, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil

    L. E. Rohde

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  1. C. B. Pilla
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  2. C. A. Pereira
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  3. A. V. Fin
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  4. F. V. Aquino
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  5. A. Botta
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  6. L. DalleMulle
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  7. C. P. Ricachinevsky
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  8. A. J. Nogueira
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  9. F. A. Lucchese
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  10. L. E. Rohde
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Correspondence to C. B. Pilla.

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Pilla, C.B., Pereira, C.A., Fin, A.V. et al. Health-Related Quality of Life and Right Ventricular Function in the Midterm Follow-up Assessment After Tetralogy of Fallot Repair. Pediatr Cardiol 29, 409–415 (2008). https://doi.org/10.1007/s00246-007-9145-4

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  • DOI: https://doi.org/10.1007/s00246-007-9145-4

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