Abstract
Inorganic lead exposure was studied in 31 volunteers employed in storage battery plant. The genotoxicity of lead was measured in terms of sister chromatid exchange (SCE). Erythrocyte δ-aminolevulinic acid dehydrogenase (ALAD) activity, urinary δ-aminolevulinic acid (U-ALA), and blood lead levels (PbBs) were also determined to evaluate some possible relations between these lead exposure indicators and the observed SCE frequencies. Blood lead concentration of 36.31 μg/dl was determined as an average level in the workers. Consequently decreased ALAD activity in erythrocytes and increased U-ALA excretion was observed in statistically higher PbBs when compared with the control group. A statistically significant correlation was observed between the PbBs and SCE frequencies (p < 0.05). Moreover, the correlation between U-ALA excretion and SCE frequencies (p < 0.01) was relatively higher than the correlation between PbBs and SCE frequencies. These results might indicate a possible mechanism of ALA mediation in the genotoxic effects of lead.
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Received: 7 September 2000/Accepted: 25 February 2001
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Duydu, Y., Süzen, H., Aydin, A. et al. Correlation Between Lead Exposure Indicators and Sister Chromatid Exchange (SCE) Frequencies in Lymphocytes from Inorganic Lead Exposed Workers. Arch. Environ. Contam. Toxicol. 41, 241–246 (2001). https://doi.org/10.1007/s002440010244
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DOI: https://doi.org/10.1007/s002440010244