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New potential solutions for the chemolysis of urinary phosphate calculi determined by an in vitro study

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Abstract

To find a more efficient solution for chemolysis of urinary calculi, several organic acids were chosen to form solutions by consulting the composition of a classic solution, Suby G. The solutions together with Renacidin, another classic solution, were designed to react with the 4 phosphate components of urinary stone. The processes were real-time measured and analysed by a focused beam reflectance measurement, and the efficiency factors were investigated and discussed in detail. The results show that several organic acids, e.g. hydroxyacetic acid, lactic acid and α-ketoglutaric acid, are more efficient than citric acid in dissolving urinary phosphate calculus. The new solutions containing the organic acids are promising for improving chemolysis treatment.

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Acknowledgments

Financial support from the National Natural Science Foundation of China (No. 21276091), Ph.D. Programmes Foundation of the Ministry of Education of China (No. 20120172110010) and Science and Technology Planning Project Foundation of Zhongshan (No. 2014A1FC120) are greatly appreciated.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Urology, Xiaolan Hospital of Southern Medical University, Zhongshan, 528415, China

    Jinqing Zhang & Jingfan Hong

  2. School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510640, China

    Shuo Wang & Yanbin Jiang

  3. Department of Urology, Zhujiang Hospital of Southern Medical University, Guangzhou, 510280, China

    Jinqing Zhang & Chunxiao Liu

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  1. Jinqing Zhang
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  2. Shuo Wang
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  3. Jingfan Hong
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  4. Chunxiao Liu
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  5. Yanbin Jiang
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Corresponding authors

Correspondence to Chunxiao Liu or Yanbin Jiang.

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Zhang, J., Wang, S., Hong, J. et al. New potential solutions for the chemolysis of urinary phosphate calculi determined by an in vitro study. Urolithiasis 43, 147–153 (2015). https://doi.org/10.1007/s00240-014-0745-1

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  • DOI: https://doi.org/10.1007/s00240-014-0745-1

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