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Ureteral stones due to systemic mastocytosis: diagnostic and therapeutic characteristics

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Abstract

Urolithiasis is expected to cause a considerable complication in patients with systemic mastocytosis. The aim of the present report is to demonstrate that due to pathological activation and irritability of mast cells, special features in the diagnostic investigation and therapy of urolithiasis have to be considered in patients with systemic mastocytosis. The clinical presentation, diagnostic investigation and therapeutic procedure of urolithiasis in a patient with systemic mastocytosis are described. Urolithiasis may be a significant complication of systemic mastocytosis. Non-contrast CT is the main tool for diagnosing urolithiasis after a detailed history and clinical exam. Patients with systemic mastocytosis should receive a premedication composed of a glucocorticoid and H1- and H2-histamine receptor antagonists. An increased vulnerability of mucosal tissues is expected in patients with systemic mastocytosis that may limit the options of operative and postoperative therapy. Opioids should be used cautiously for analgesia in patients with systemic mastocytosis.

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Conflict of interest statement

No competing financial interests exist.

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Authors and Affiliations

  1. Institute of Human Genetics, University Hospital of Bonn, Wilhelmstrasse 31, 53111, Bonn, Germany

    Gerhard J. Molderings

  2. Department of Urology, Evangelische Kliniken Bonn, Waldkrankenhaus, Waldstrasse 73, 53177, Bonn, Germany

    Gerold Solleder & Roland Vorreuther

  3. Department for Internal Medicine, Evangelische Kliniken Bonn, Waldkrankenhaus, Waldstrasse 73, 53177, Bonn, Germany

    Ulrich W. Kolck & Jürgen Homann

  4. Department of Surgery, Evangelische Kliniken Bonn, Waldkrankenhaus, Waldstrasse 73, 53177, Bonn, Germany

    Detlev Schröder

  5. Department of Pharmacology and Toxicology, University of Bonn, Reuterstrasse 2b, 53113, Bonn, Germany

    Ivar von Kügelgen

Authors
  1. Gerhard J. Molderings
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  2. Gerold Solleder
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  3. Ulrich W. Kolck
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  4. Jürgen Homann
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  5. Detlev Schröder
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  6. Ivar von Kügelgen
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  7. Roland Vorreuther
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Correspondence to Gerhard J. Molderings.

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Molderings, G.J., Solleder, G., Kolck, U.W. et al. Ureteral stones due to systemic mastocytosis: diagnostic and therapeutic characteristics. Urol Res 37, 227–229 (2009). https://doi.org/10.1007/s00240-009-0198-0

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  • DOI: https://doi.org/10.1007/s00240-009-0198-0

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