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Effects of calcium supplementation on body weight reduction in overweight calcium stone formers

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Abstract

A randomized, placebo-controlled trial was conducted in overweight calcium stone-forming (CSF) patients, to evaluate the effect of calcium supplementation associated with a calorie-restricted diet on body weight (BW) and fat reduction and its potential changes upon serum and urinary parameters. Fifteen patients were placed on a hypocaloric diet for 3 months, supplemented with either calcium carbonate (CaCO3, n = 8) or placebo (n = 7), 500 mg bid. Blood and 24-h urine samples were collected and body composition was assessed at baseline and after the intervention. At the end of the study, final BW was significantly lower vs baseline in both CaCO3 (74 ± 14 vs. 80 ± 14 kg, P = 0.01) and placebo groups (80 ± 10 vs. 87 ± 9 kg, P = 0.02) but the mean percentage of loss of body weight and body fat did not differ between CaCO3 and placebo (7.0 ± 2.0 vs. 8.0 ± 3.0%, P = 0.40 and 13.0 ± 7.0 vs. 13.0 ± 10.0%; P = 0.81, respectively). After CaCO3 or placebo, no significant differences versus baseline were observed for urinary parameters in both CaCO3 and placebo, except for a higher mean urinary citrate in placebo group. These data suggest that increasing calcium intake by calcium carbonate supplementation did not contribute to a further reduction of BW and fat in overweight CSF patients submitted to a hypocaloric diet nor altered urinary lithogenic parameters.

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References

  1. Coe FL, Evan A, Worcester E (2005) Kidney stone disease. J Clin Invest 115:2598–2608. doi:10.1172/JCI26662

    Article  PubMed  CAS  Google Scholar 

  2. Moe OW (2006) Kidney stones: pathophysiology and medical management. Lancet 367:333–344. doi:10.1016/S0140-6736(06)68071-9

    Article  PubMed  CAS  Google Scholar 

  3. Curhan GC, Willet WC, Rimm EB, Speizer FE, Stampfer MJ (1998) Body size and risk of kidney stones. J Am Soc Nephrol 9:1645–1652

    PubMed  CAS  Google Scholar 

  4. Siener R, Glatz S, Nicolay C, Hesse A (2004) The role of overweight and obesity in calcium oxalate stone formation. Obes Res 12:106–113. doi:10.1038/oby.2004.14

    Article  PubMed  CAS  Google Scholar 

  5. Taylor EN, Stampfer MJ, Curhan GC (2005) Obesity, weight gain, and the risk of kidney stones. JAMA 293:455–462. doi:10.1001/jama.293.4.455

    Article  PubMed  CAS  Google Scholar 

  6. Maalouf NM, Sakhaee K, Parks JH, Coe FL, Adams-Huet B, Pak CYC (2004) Association of urinary pH with body weight in nephrolithiasis. Kidney Int 65:1422–1425. doi:10.1111/j.1523-1755.2004.00522.x

    Article  PubMed  Google Scholar 

  7. Zemel MB, Thompson W, Milstead A, Morris K, Campbell P (2004) Calcium and dairy acceleration of weight and fat loss during energy restriction in obese adults. Obes Res 12:582–590. doi:10.1038/oby.2004.67

    Article  PubMed  CAS  Google Scholar 

  8. Zemel MB, Richards J, Mathis S, Milstead A, Gebhardt L, Silva E (2005) Dairy augmentation of total and central fat loss in obese subjects. Int J Obes 29:391–397. doi:10.1038/sj.ijo.0802880

    Article  CAS  Google Scholar 

  9. Zemel MB, Richards J, Milstead A, Campbell P (2005) Effects of calcium and dairy on body composition and weight loss in African-American Adults. Obes Res 13:1218–1225. doi:10.1038/oby.2005.144

    Article  PubMed  CAS  Google Scholar 

  10. Zemel MB (2003) Role of dietary calcium and dairy products in modulating adiposity. Lipids 38:139–146. doi:10.1007/s11745-003-1044-6

    Article  PubMed  CAS  Google Scholar 

  11. Zemel MB (2003) Mechanisms of dairy modulation of adiposity. J Nutr 133:252S–256S

    PubMed  Google Scholar 

  12. Shahkhalili Y, Murset C, Meirim I, Duruz E, Guinchard S, Cavadini C et al (2001) Calcium supplementation of chocolate: effect on cocoa butter digestibility and blood lipids in humans. Am J Clin Nutr 73:246–252

    PubMed  CAS  Google Scholar 

  13. Vaskonen T (2003) Dietary minerals and modification of cardiovascular risk factors. J Nutr Biochem 14:492–506. doi:10.1016/S0955-2863(03)00074-3

    Article  PubMed  CAS  Google Scholar 

  14. Ricci TA, Chowdhury HA, Heymsfield SB, Stahl T, Pierson RN, Shapses AS (1998) Calcium supplementation suppresses bone turnover during weight reduction in postmenopausal women. J Bone Miner Res 13:1045–1050. doi:10.1359/jbmr.1998.13.6.1045

    Article  PubMed  CAS  Google Scholar 

  15. Shapses SA, Heshka S, Heymsfield SB (2004) Effect of calcium on weight and fat loss in women. J Clin Endocrinol Metab 89:632–637. doi:10.1210/jc.2002-021136

    Article  PubMed  CAS  Google Scholar 

  16. Gunther CW, Legowski PA, Lyle RM, McCabe GP, Eagan MS, Peacock M et al (2005) Dairy products do not lead to alterations in body weight or fat mass in young women in a 1-y intervention. Am J Clin Nutr 81:751–756

    PubMed  CAS  Google Scholar 

  17. Reid IR, Horne A, Mason B, Ames R, Bava U, Gamble GD (2005) Effects of calcium supplementation on body weight and blood pressure in normal older women: a randomized controlled trial. J Clin Endocrinol Metab 90:3824–3829. doi:10.1210/jc.2004-2205

    Article  PubMed  CAS  Google Scholar 

  18. Lorenzen JK, Molgaard C, Michaensen KF, Astrup A (2006) Calcium supplementation for 1 y does not reduce body weight or fat mass in young girls. Am J Clin Nutr 83:18–23

    PubMed  CAS  Google Scholar 

  19. Riedt CS, Schlussel Y, Von Thun N, Ambia-Sobhan H, Stahl T, Field MP et al (2007) Premenopausal overweight women do not lose bone during moderate weight loss with adequate or higher calcium intake. Am J Clin Nutr 85:972–980

    PubMed  CAS  Google Scholar 

  20. Curhan GC, Willet WC, Rimm EB, Stampfer MJ (1993) A prospective study of dietary calcium and other nutrients and the risk of symptomatic kidney stones. N Engl J Med 328:833–838. doi:10.1056/NEJM199303253281203

    Article  PubMed  CAS  Google Scholar 

  21. Borghi L, Schianchi T, Meschi T, Guerra A, Allegri F, Maggiore U et al (2002) Comparison of two diets for the prevention of recurrent stones in idiopathic hypercalciuria. N Engl J Med 346:77–84. doi:10.1056/NEJMoa010369

    Article  PubMed  CAS  Google Scholar 

  22. Domrongkitchaiporn S, Sopassathit W, Stitchantrakul W, Prapaipanich S, Ingsathit A, Rajatanavin R (2004) Schedule of taking calcium supplement and the risk of nephrolithiasis. Kidney Int 65:1835–1841. doi:10.1111/j.1523-1755.2004.00587.x

    Article  PubMed  CAS  Google Scholar 

  23. National Kidney Foundation–Kidney Disease Outcome Quality Iniciative (2000) Clinical practice guidelines for nutrition in chronic renal failure. Am J Kidney Dis 35:17–37

    Article  Google Scholar 

  24. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412–419. doi:10.1007/BF00280883

    Article  PubMed  CAS  Google Scholar 

  25. Tiselius HG (1991) Aspects on estimation of the risk of calcium oxalate crystallization in urine. Urol Int 47:255–259

    Article  PubMed  CAS  Google Scholar 

  26. Dos Santos LC, Martini LA, Cintra Ide P, Fisberg M (2005) Relationship between calcium intake and body mass index in adolescents. Arch Latinoam Nutr 55:345–349

    PubMed  Google Scholar 

  27. Zemel MB, Shi H, Greer B, Dirienzo D, Zemel P (2000) Regulation of adiposity by dietary calcium. FASEB J 14:1132–1138

    PubMed  CAS  Google Scholar 

  28. Shi H, Dirienzo D, Zemel MB (2001) Effects of dietary calcium on adipocyte lipid metabolism and body weight regulation in energy-restricted aP2-agouti transgenic mice. FASEB J 15:291–293

    PubMed  CAS  Google Scholar 

  29. Pittas AG, Lau J, Hu FB, Dawson-Hughes B (2007) Review: the role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab 92:2017–2029. doi:10.1210/jc.2007-0298

    Article  PubMed  CAS  Google Scholar 

  30. Melanson EL, Donahoo WT, Dong F, Ida T, Zemel MB (2005) Effect of low-and high-calcium dairy- based diets on macronutrient oxidation in humans. Obes Res 13:2102–2112. doi:10.1038/oby.2005.261

    Article  PubMed  CAS  Google Scholar 

  31. Ryan AS, Berman DM, Nicklas BJ, Sinha M, Gingerich RL, Meneilly GS et al (2003) Plasma adiponectin and leptin levels, body composition, and glucose utilization in adult women with wide ranges of age and obesity. Diabetes Care 26:2383–2388. doi:10.2337/diacare.26.8.2383

    Article  PubMed  CAS  Google Scholar 

  32. Meier U, Gressner AM (2004) Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin. Clin Chem 50:1511–1525. doi:10.1373/clinchem.2004.032482

    Article  PubMed  CAS  Google Scholar 

  33. Grundy SM (2004) Obesity, metabolic syndrome, and cardiovascular disease. J Clin Endocrinol Metab 89:2595–2600. doi:10.1210/jc.2004-0372

    Article  PubMed  CAS  Google Scholar 

  34. Ryan AS, Nicklas BJ, Berman DM, Elahi D (2003) Adiponectin levels do not change with moderate dietary induced weight loss and exercise in obese postmenopausal women. Int J Obes 27:1066–1071. doi:10.1038/sj.ijo.0802387

    Article  CAS  Google Scholar 

  35. Heller HJ, Doerner MF, Brinkley LJ, Adams-Huet B, Pak CYC (2003) Effect of dietary calcium on stone forming propensity. J Urol 169:470–474. doi:10.1016/S0022-5347(05)63935-3

    Article  PubMed  CAS  Google Scholar 

  36. Domrongkitchaiporn S, Ongphiphadhanakul B, Stitchantrakul W, Chansirikarn S, Puavilai G, Rajatanavin R (2002) Risk of calcium oxalate nephrolithiasis in postmenopausal women supplemented with calcium or combined calcium and estrogen. Maturitas 41:149–156. doi:10.1016/S0378-5122(01)00277-8

    Article  PubMed  CAS  Google Scholar 

  37. Lewandowski S, Rodgers A (2004) Renal response to lithogenic and anti-lithogenic supplement challenges in a stone-free population group. J Ren Nutr 14:170–179. doi:10.1053/j.jrn.2004.04.007

    Article  PubMed  Google Scholar 

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Acknowledgments

Research was supported by grants from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPQ–Grant 402128/2005-2), Coordenação de Aperfeiçoamento Pessoal de Nível Superior (CAPES) and Fundação Oswaldo Ramos-Hospital do Rim e Hipertensão from Universidade Federal de São Paulo. The authors wish to express their thanks to Silvia Regina Moreira for technical assistance.

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Authors and Affiliations

  1. Nutrition Program, Universidade Federal de São Paulo, São Paulo, SP, Brazil

    Viviane Barcellos Menon, Alessandra Calábria Baxmann & Leila Froeder

  2. Nephrology Division, Universidade Federal de São Paulo, Rua Botucatu 740, Vila Clementino, São Paulo, SP, 04023-900, Brazil

    Ita Pfeferman Heilberg

  3. Nutrition Department, Universidade de São Paulo, São Paulo, SP, Brazil

    Lígia Araújo Martini

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  1. Viviane Barcellos Menon
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  2. Alessandra Calábria Baxmann
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Correspondence to Ita Pfeferman Heilberg.

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Menon, V.B., Baxmann, A.C., Froeder, L. et al. Effects of calcium supplementation on body weight reduction in overweight calcium stone formers. Urol Res 37, 133–139 (2009). https://doi.org/10.1007/s00240-009-0187-3

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  • DOI: https://doi.org/10.1007/s00240-009-0187-3

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