Abstract
Urolithiasis has not been extensively researched in the African continent due to a general lack of facilities and resources. Consideration of the few published papers indicates that there are some regions where the occurrence of stones is extremely rare. South Africa is unique in two respects. Firstly, it has both stone-prone and stone-free population groups and secondly, it is an African country in which a fair amount of research has been conducted in this field. These studies have shown that routine urine parameters cannot explain stone rarity, but that structural differences of inhibitory urinary proteins appear to be important. Similarly, the studies have demonstrated that common dietary components cannot necessarily be correlated with urine composition, particularly oxaluria, nor can they necessarily explain stone rarity, but that the role of oxalate-degrading bacteria has the potential to offer explanatory insights. By investigating the factors influencing stone rarity, those affecting stone formation have been concomitantly scrutinized. As a result, it is suggested that a paradigm shift from a focus on pathology to one on physiology is needed in urolithiasis research in general.
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References
Johnson O (1995) Vessical calculus in Ethiopian children. Ethiop Med J 33:31
Angwafo F, Daudon M, Wonkam A, Kuwong P, Kropp K (2000) Pediatric urolithiasis in sub-Saharan Africa: a comparative study in two regions of Cameroon. Eur Res 37:106
Vanwaeyenbergh J, Vergauwe D, Verbeeck R (1995) Infrared spectrometric analysis of endemic bladder stones in Niger. Eur Urol 27:154
Harrache D, Mesri A, Addou A, Semmoud A, Lacour B, Daudon M (1997) Urolithiasis in children in West Algeria. Ann Urol 31:84
Loutfi A, Van Reen R, Abdel Hamid G (1978) Studies on bladder stone disease in Egyptian children. VIII. Biochemical studies of the urine. J Egypt Med Assoc 61:621
Whalley N, Moraes M, Shar T, Pretorius S, Meyers M (1998) Lithogenic risk factors in the urine of black and white subjects. Br J Urol 82:785
Mkony C, Chuwa L, Kahamba J, Mteta K, Mbembati N (1991) Urinary stone disease in Dar es Salaam. East Afr Med J 68:461
Ibrahim A (1978) The relationship between urinary bilharzias and urolithiasis in the Sudan. Br J Urol 50:294
Kambal A, Wahab E, Khattab A (1979) Urolithiasis in Sudan. Trop Geogr Med 31:75
Kambal A, Wahab A, Khattab A, Zaki J (1981) Urolithiasis in the Sudan. Studies on a stone-prone and a stone-free population. Br J Urol 53:7
Esho J (1978) The rarity of urinary calculus in Nigeria. Trop Geogr Med 30:86
Esho J (1978) Analysis of urinary calculi formed by Nigerians. Eur Urol 4:288
Olapade-Olaopa E, Agunloye A, Ogunlana D, Owoaje E, Marinho T (2004) Chronic dehydration and syptomatic upper urinary tract stones in young adults in Ibadan, Nigeria. West Afr J Med 23:146
Holmes RP, Assimos DG (2004) The impact of dietary oxalate on kidney stone formation. Urol Res 32:311
Lewandowski S, Rodgers AL, Schloss I (2001) The influence of a high-oxalate/low-calcium diet on calcium oxalate renal stone risk factors in non-stone-forming black and white South African subjects. BJU Int 87:307
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Rodgers, A. The riddle of kidney stone disease: lessons from Africa. Urol Res 34, 92–95 (2006). https://doi.org/10.1007/s00240-005-0017-1
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DOI: https://doi.org/10.1007/s00240-005-0017-1