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Gene Conversion and Functional Divergence in the β-Globin Gene Family

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Abstract

Different models of gene family evolution have been proposed to explain the mechanism whereby gene copies created by gene duplications are maintained and diverge in function. Ohta proposed a model which predicts a burst of nonsynonymous substitutions following gene duplication and the preservation of duplicates through positive selection. An alternative model, the duplication–degeneration–complementation (DDC) model, does not explicitly require the action of positive Darwinian selection for the maintenance of duplicated gene copies, although purifying selection is assumed to continue to act on both copies. A potential outcome of the DDC model is heterogeneity in purifying selection among the gene copies, due to partitioning of subfunctions which complement each other. By using the dN/dS (ω) rate ratio to measure selection pressure, we can distinguish between these two very different evolutionary scenarios. In this study we investigated these scenarios in the β-globin family of genes, a textbook example of evolution by gene duplication. We assembled a comprehensive dataset of 72 vertebrate β-globin sequences. The estimated phylogeny suggested multiple gene duplication and gene conversion events. By using different programs to detect recombination, we confirmed several cases of gene conversion and detected two new cases. We tested evolutionary scenarios derived from Ohta’s model and the DDC model by examining selective pressures along lineages in a phylogeny of β-globin genes in eutherian mammals. We did not find significant evidence for an increase in the ω ratio following major duplication events in this family. However, one exception to this pattern was the duplication of γ-globin in simian primates, after which a few sites were identified to be under positive selection. Overall, our results suggest that following gene duplications, paralogous copies of β-globin genes evolved under a nonepisodic process of functional divergence.

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Acknowledgments

G.A. was supported by a grant from the Mexican Council for Science and Technology (CONACYT). J.P.B. and Z.Y. were supported by grant 31/G14969 from the Biotechnology and Biological Sciences Research Council (BBSRC, UK).

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Authors and Affiliations

  1. Department of Biology, University College London, Darwin Building, Gower Street, London, WC1E 6BT, England

    Gabriela Aguileta, Joseph P. Bielawski & Ziheng Yang

  2. Department of Biology, Dalhousie University, Halifax, Nova Scotia, B3H 4J1, Canada

    Joseph P. Bielawski

Authors
  1. Gabriela Aguileta
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  2. Joseph P. Bielawski
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  3. Ziheng Yang
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Corresponding author

Correspondence to Joseph P. Bielawski.

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Aguileta, G., Bielawski, J.P. & Yang, Z. Gene Conversion and Functional Divergence in the β-Globin Gene Family. J Mol Evol 59, 177–189 (2004). https://doi.org/10.1007/s00239-004-2612-0

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  • DOI: https://doi.org/10.1007/s00239-004-2612-0

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