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Proton MR spectroscopic imaging in multiple sclerosis

  • Diagnostic Neuroradiology
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Abstract.

We studied 24 patients with multiple sclerosis (MS) by proton magnetic resonance spectroscopic imaging (1H-MRSI) to assess the neurochemical pathology of the white-matter lesions (WML) and normal-appearing white matter (NAWM). Our 1H-MRSI technique allowed simultaneous measurement of N-acetylaspartate (NAA), choline-containing compounds (Cho), and creatine plus phosphocreatine (Cr) signal intensities from four 15-mm slices divided into 0.84 ml single-volume elements. In WML we found significantly lower NAA/Cr and NAA/Cho ratios and a significantly higher Cho/Cr ratio than in NAWM or control white matter. In NAWM, NAA/Cr and Cho/Cr were significantly lower than in control white matter. 1H-MRSI was compatible with damage to myelin in WML, and with axonal damage and/or dysfunction in WML and NAWM. These findings extend data on involvement of NAWM in MS beyond the abnormalities visible on MRI.

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Authors and Affiliations

  1. Istituto di Scienze Neurologiche, Seconda Università di Napoli, Piazza Miraglia 2, 80138 Napoli, Italy, Italy

    G. Tedeschi & S. Bonavita

  2. Department of Neuroimmunology, National Institute of Neurological Disease and Stroke, National Institutes of Health, Bethesda, MD, USA, USA

    H. McFarland & N. Richert

  3. Laboratory of Diagnostic Radiology Research, National Institutes of Health, Bethesda, MD, USA, USA

    J. Duyn & J. Frank

Authors
  1. G. Tedeschi
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  2. S. Bonavita
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  3. H. McFarland
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  4. N. Richert
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  5. J. Duyn
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  6. J. Frank
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Tedeschi, G., Bonavita, S., McFarland, H. et al. Proton MR spectroscopic imaging in multiple sclerosis. Neuroradiology 44, 37–42 (2002). https://doi.org/10.1007/s002340100584

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  • DOI: https://doi.org/10.1007/s002340100584

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