Abstract
Purpose
This study investigates the feasibility of ultrafast fluid sensitive techniques for evaluation of pediatric spinal cord syrinx. Rapid imaging could obviate the need for sedation, which is often required for children undergoing lengthier standard spine imaging.
Methods
Children undergoing standard spine imaging for Chiari malformation, suspected Chiari malformation, or syrinx were included. Patients who provided informed consent were imaged with rapid acquisition sagittal and axial T2 HASTE spine sequences in addition to standard spine imaging. Standard and rapid spine imaging were then reviewed separately by a pediatric neuroradiologist. The presence or absence of syrinx, syrinx diameter, and length were assessed. The degree of cerebellar tonsillar ectopia, conus position, and evaluation of the filum were also recorded.
Results
Seventy-six patients aged 1 month to 18 years (mean 7 years) met the inclusion criteria. The sensitivity and specificity of rapid spine imaging for syrinx was 87.8% and 94.7% respectively. All syrinxes > 2.3 mm in diameter were identified with the rapid spine sequences. There was no statistically significant difference between rapid and standard spine imaging in assessment of syrinx diameter or length. Compared with standard spine imaging, rapid spine sequences demonstrated a 100% sensitivity for low-lying conus and a 98.2% sensitivity for cerebellar tonsillar ectopia. The filum was identified on only 31.6% of the rapid spine studies.
Conclusion
Rapid T2 imaging demonstrated a high sensitivity for the presence and extent of spinal cord syrinx and may provide an alternative to traditional, lengthier standard spine imaging in selected patients.
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Maura E. Ryan: Study conception, design, data collection, manuscript preparation. Alok Jaju: Study conception, design, data collection, manuscript preparation. Karen Rychlik: statistical analysis. Robin Bowman: Manuscript preparation and review.
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The study was approved by the Institutional Review Board of Ann & Robert H. Lurie Children’s Hospital of Chicago.
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Written informed consent was obtained from parents and/or legal guardians of all study participants.
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Ryan, M.E., Jaju, A., Rychlik, K. et al. Feasibility of rapid spine magnetic resonance evaluation for spinal cord syrinx in the pediatric population. Neuroradiology 64, 1879–1885 (2022). https://doi.org/10.1007/s00234-022-02960-7
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DOI: https://doi.org/10.1007/s00234-022-02960-7