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Lesion location associated with balance recovery and gait velocity change after rehabilitation in stroke patients

  • Functional Neuroradiology
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Abstract

Purpose

Impaired gait function after stroke contributes strongly to overall patient disability. However, the response to rehabilitation varies between individuals. The aims of this study were to identify predictors of gait velocity change and to elucidate lesion location associated with change of balance and gait function.

Methods

We reviewed 102 stroke patients. The patients were divided into two groups according to gait ability post-rehabilitation, and we analyzed differences in their characteristics, such as demographic information, lesion factors, and initial balance function. Multivariate regression analyses were performed to examine the predictors of rehabilitation response. Lesion location and volume were measured on brain magnetic resonance images. We generated statistical maps of the lesions related to functional gains in gait and balance using voxel-based lesion symptom mapping (VLSM).

Results

The group of patients who regained independent ambulation function showed a smaller lesion size, a shorter duration from stroke onset, and higher initial balance function. In the regression model, gait velocity changes were predicted with the initial Berg balance scale (BBS) and duration post-onset. Absolute BBS changes were also correlated with the duration post-onset and initial BBS, and relative BBS changes were predicted by the baseline BBS. Using VLSM, lesion locations associated with gait velocity changes and balance adjusting for other factors were the insula, internal capsule, and adjacent white matter.

Conclusion

Initial balance function as well as the interval between stroke onset and the initiation of therapy might influence balance recovery and gait velocity changes. Damage to the insula and internal capsule also affected gait velocity change after rehabilitation.

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Authors and Affiliations

  1. Department of Rehabilitation Medicine, Bundang Jesaeng General Hospital, 20, Seohyeon-ro 180 beon-gil, Bundang-gu, Seoungnam-si, 13590, Gyeonggi-do, Republic of Korea

    Hyun Im Moon, Hyo Jeong Lee & Seo Yeon Yoon

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  1. Hyun Im Moon
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Correspondence to Hyun Im Moon.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee (IRB No.: RM17-01) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study formal consent is not required.

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Moon, H.I., Lee, H.J. & Yoon, S.Y. Lesion location associated with balance recovery and gait velocity change after rehabilitation in stroke patients. Neuroradiology 59, 609–618 (2017). https://doi.org/10.1007/s00234-017-1840-0

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