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In vivo visualization and analysis of 3-D hemodynamics in cerebral aneurysms with flow-sensitized 4-D MR imaging at 3 T

  • Diagnostic Neuroradiology
  • Published:
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Abstract

Introduction

Blood-flow patterns and wall shear stress (WSS) are considered to play a major role in the development and rupture of cerebral aneurysms. These hemodynamic aspects have been extensively studied in vitro using geometric realistic aneurysm models. The purpose of this study was to evaluate the feasibility of in vivo flow-sensitized 4-D MR imaging for analysis of intraaneurysmal hemodynamics.

Methods

Five cerebral aneurysms were examined using ECG-gated, flow-sensitized 4-D MR imaging at 3 T in three patients. Postprocessing included quantification of flow velocities, visualization of time-resolved 2-D vector graphs and 3-D particle traces, vortical flow analysis, and estimation of WSS. Flow patterns were analyzed in relation to aneurysm geometry and aspect ratio.

Results

Magnitude, spatial and temporal evolution of vortical flow differed markedly among the aneurysms. Particularly unstable vortical flow was demonstrated in a wide-necked parophthalmic ICA aneurysm (high aspect ratio). Relatively stable vortical flow was observed in aneurysms with a lower aspect ratio. Except for a wide-necked cavernous ICA aneurysm (low aspect ratio), WSS was reduced in all aneurysms and showed a high spatial variation.

Conclusion

In vivo flow-sensitized 4-D MR imaging can be applied to analyze complex patterns of intraaneurysmal flow. Flow patterns, distribution of flow velocities, and WSS seem to be determined by the vascular geometry of the aneurysm. Temporal and spatial averaging effects are drawbacks of the MR-based analysis of flow patterns as well as the estimation of WSS, particularly in small aneurysms. Further studies are needed to establish a direct link between definitive flow patterns and different aneurysm geometries.

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Acknowledgements

This work was supported in part by grant number SNF 320000-113492/1 received from the Swiss National Science Foundation (SNF).

Conflict of interest statement

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Neuroradiology, Institute of Radiology, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland

    Stephan Meckel, Ernst-Wilhelm Radü & Stephan G. Wetzel

  2. Department of Diagnostic Radiology, Medical Physics, University Hospital Freiburg, Hugstetter Str. 55, 79106, Freiburg, Germany

    Aurelien F. Stalder & Michael Markl

  3. MR Physics, Institute of Radiology, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland

    Francesco Santini

  4. Neurointerventional Service, Department of Clinical Neurosciences, Geneva University Hospitals, Rue Micheli-Du-Crest 24, 1211, Geneva, Switzerland

    Daniel A. Rüfenacht

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  1. Stephan Meckel
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  2. Aurelien F. Stalder
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  3. Francesco Santini
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Correspondence to Stephan Meckel.

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Meckel, S., Stalder, A.F., Santini, F. et al. In vivo visualization and analysis of 3-D hemodynamics in cerebral aneurysms with flow-sensitized 4-D MR imaging at 3 T. Neuroradiology 50, 473–484 (2008). https://doi.org/10.1007/s00234-008-0367-9

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