Abstract
Introduction
Glubran 2 is a cyanoacrylate-based synthetic glue modified by the addition of a monomer synthesized by the manufacturer. With this material it is possible to obtain the stability of endovascular embolization that is needed to treat tumours and vascular disease.
Material and methods
We report our 3-year experience of the use of Glubran for treating extracerebral tumours, spinal tumours, spinal arteriovenous malformations, and brain and spine dural fistulae. Glubran 2 was diluted with Lipiodol and injected in a continuous column with the flow rate monitored by seriography. The injection was stopped when retrograde flow was displayed in the afferent vessel.
Results
There were no periprocedural or subsequent clinical complications and the glue resulted in successful selective permanent occlusion with intralesional penetration similar to the angiographic features of microcatheterization.
Conclusions
The embolization procedure was technically straightforward and relatively safe. However, Glubran 2 can be difficult to use and the procedure does carry major risks for patients. Glue injection requires in-depth study of the lesion, its circulation and the collateral circulation to avoid severe complications due to inappropriate use.
Similar content being viewed by others
References
Leonardi M, Barbara C, Simonetti L, Giardino R, Nicoli Aldini N, Fini M, Martini L, Masetti L, Joechler M, Roncaroli F (2002) Glubran 2: a new acrylic glue for neuroradiological endovascular use – experimental study on animals. Interv Neuroradiol 8:245–250
Leonardi M, Cenni P, Simonetti L, Bozzao A, Romano A, Bonamini M, Fantozzi LM, Fini G (2003) Glubran 2: a new acrylic glue for neuroradiological endovascular use. A complementary histological study. Interv Neuroradiol 9:249–254
Simonetti L, Raffi L, Cenni P, Andreoli A, Calbucci F, Leonardi M (2004) Presurgical embolization of intracranial extra-axial tumours using Glubran 2: our experience in 14 patients. Riv Neuroradiol 17:645–658
Boriani S, Weinstein JN (1997) Differential diagnosis and surgical treatment of primary benign and malignant neoplasms. In: Frymoyer JW (ed) The adult spine: principles and practice. Lippincott-Raven, Philadelphia, pp 951–987
Roy-Camille R, Monpierre H, Mazel Ch, Saillant G (1997) Technique de vertebrectomie totale lombaire. In: Roy-Camille R (ed) Rachis dorsal et lombaire, Septieme Journees d’Orthopedie de la Pitié. Masson, Paris, pp 49–52
Gellad FE, Sadato N, Numaguchi Y, Levine A (1990) Vascular metastatic lesions of the spine: preoperative embolization. Radiology 176:683–686
Perini S, Maschio M, Beltramello A, Faccioli F, Benati A (1988) Angiografia ed embolizzazione dei tumori vascolarizzati del rachide. Riv Neuroradiol 1:37–52
Schumacher M, Klisch J, Spetzger U, Zenter J (2002) The role of embolization in the interdisciplinary treatment of extradural space-occupying lesions in the vertebral canal. Klin Neuroradiol 12:160–167
Shi HB, Suh DC, Lee HK, Lim SM, Kim DH, Choi CG, Lee CS, Rhim SC (1999) Preoperative transarterial embolization of spinal tumor: embolization techniques and results. AJNR Am J Neuroradiol 20:2009–2015
Raffi L, Simonetti L, Cenni P, Bandiera S, Gasbarrini A, Boriani S, Leonardi M (2003) Presurgical embolization of spinal tumours using Glubran 2 acrylic glue. Interv Neuroradiol 9:339–349
Leonardi M, Barbara C, Simonetti L (2002) Glubran 2: a new acrylic glue approved for endovascular use. Proceedings of the American Society of Neuroradiology (ASNR) 40th Annual Meeting, Vancouver, British Columbia, Canada, May, p 320
Leonardi M, Barbara C, Simonetti L et al (2002) Endovascular behaviour of Glubran 2: an experimental study. J Neuroradiol 29:25
Leonardi M, Barbara C, Simonetti L et al (2002) Glubran 2: a new acrylic glue for neuroradiological endovascular use. Interv Neuroradiol 8:245–250
Leonardi M, Simonetti L, Marliani AF et al (2002) Embolizzazione prechirurgica di neoplasie della base cranica con colla acrilica (Glubran 2): prime esperienze. Atti del Congresso Nazionale della SIB. Milano
Maciunas RB (1988) Endovascular neurological intervention. American Association of Neurological Surgeons, Park Ridge, IL., pp 139–284
Manelfe C, Lasjaunias P, Ruscalleda J (1986) Preoperative embolization of intracranial meningiomas. AJNR Am J Neuroradiol 7:963–972
Valavanis A (1997) Embolization of intracranial and skull base tumours. Riv Neuroradiol 10:83–91
Valavanis A (2000) Interventional neuroradiology in skull base tumours. Interv Neuroradiol 13:149–178
Conflict of interest statement
We declare that we have no conflict of interest.
Author information
Authors and Affiliations
Corresponding author
Additional information
This paper was awarded the Lucien Appel Prize ESNR 2003.
Rights and permissions
About this article
Cite this article
Raffi, L., Simonetti, L., Cenni, P. et al. Use of Glubran 2 acrylic glue in interventional neuroradiology. Neuroradiology 49, 829–836 (2007). https://doi.org/10.1007/s00234-007-0238-9
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00234-007-0238-9