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Modified technique to create morphologically reproducible elastase-induced aneurysms in rabbits

  • Interventional Neuroradiology
  • Published:
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Abstract

Introduction

The purpose of this study was to create morphologically reproducible elastase-induced model aneurysms in rabbits.

Methods

We created 120 elastase-induced aneurysms in rabbits using two different methods: the standard technique (group 1, n=62) and a modified technique (group 2, n=58). In the standard technique a small cutdown with a focal area of exposure of the mid-right common carotid artery (RCCA) was employed, while in the modified technique the RCCA was completely exposed to its origin. We measured aneurysm sizes (neck diameter, width and height) in the two groups. The aneurysm sizes were compared between the two groups using Student’s t test, and the standard deviations of the aneurysm sizes were compared between the groups using the F test.

Results

The mean aneurysm neck size, width and height in group 1 were 3.4±1.2 mm, 3.8±1.0 mm and 8.0±1.7 mm, respectively, and in group 2, were 3.2±0.9 mm, 3.7±0.6 mm and 9.1±1.8 mm, respectively. The differences in mean aneurysm neck and width between the two groups were not significant (P>0.05). However, there were significant differences in the standard deviation of these two parameters between the two groups (P<0.05 and P<0.01, respectively). The mean aneurysm height in group 2 was larger than in group 1 (P<0.001), but no significant difference in the standard deviation of this parameter between the two groups was found (P>0.05).

Conclusion

The results indicate that more consistent aneurysm diameters can be created using the modified technique.

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Acknowledgements

This study was supported by National Institutes of Health grant NS42646. The authors thank Brian Hoh, MD, for his ongoing collaborative efforts.

Conflict of interest statement

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Neuroradiology Research Laboratory, Department of Radiology, Mayo Clinic, Rochester, MN, USA

    Yong Hong Ding, Mark A. Danielson, Ramanathan Kadirvel, Daying Dai, Debra A. Lewis, Harry J. Cloft & David F. Kallmes

  2. Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA

    David F. Kallmes

Authors
  1. Yong Hong Ding
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  2. Mark A. Danielson
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  3. Ramanathan Kadirvel
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  4. Daying Dai
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  5. Debra A. Lewis
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  6. Harry J. Cloft
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  7. David F. Kallmes
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Corresponding author

Correspondence to David F. Kallmes.

Additional information

Authors’ contributions

  • Guarantor of integrity of the entire study: Yonghong Ding and David F. Kallmes

  • Study concepts: Yonghong Ding and David F. Kallmes

  • Study design: David F. Kallmes and Yonghong Ding

  • Definition of intellectual content: Yonghong Ding and David F. Kallmes

  • Literature research: Yonghong Ding and David F. Kallmes

  • Clinical studies: not applicable

  • Experimental studies: Yonghong Ding, Mark A. Danielson, Ramanathan Kadirvel, Daying Dai, Debra A. Lewis, and David F. Kallmes

  • Data acquisition: Yonghong Ding, Daying Dai, Mark A. Danielson

  • Data analysis: Yonghong Ding and David F. Kallmes

  • Statistical analysis: Debra A. Lewis and Yonghong Ding

  • Manuscript preparation: Yonghong Ding

  • Manuscript editing: Yonghong Ding and David F. Kallmes

  • Manuscript review: David F. Kallmes and Harry J. Cloft

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Ding, Y.H., Danielson, M.A., Kadirvel, R. et al. Modified technique to create morphologically reproducible elastase-induced aneurysms in rabbits. Neuroradiology 48, 528–532 (2006). https://doi.org/10.1007/s00234-006-0093-0

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  • DOI: https://doi.org/10.1007/s00234-006-0093-0

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