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Exosome Analysis: A Promising Biomarker System with Special Attention to Saliva

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Abstract

Today, exosome-related studies have become a focus in science and technology. Recently, three scientists won the Nobel Prize for determining the mechanisms of exosomal transport, making exosomes a promising biomarker system for disease diagnosis and treatment. This review provides a general introduction of exosomes and explores the recent progress on the function, application, isolation, and identification of exosomes as biomarkers in blood and other body fluids, especially in saliva. Detailed information of exosomal proteins and RNAs is discussed in the paper because of their ability to determine the function of exosomes. Due to their noninvasive assessment for quick and convenient diagnosis of diseases, salivary exosomes may well be promising biomarkers.

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Acknowledgments

This work was supported by Grants 81200762 from National Natural Science Foundation of China, by the funding from Peking University School of Stomatology (PKUSS20130210), and by the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry.

Conflict of interest

The authors declared that they have no competing interests.

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Authors and Affiliations

  1. Department of Orthodontics, School of Stomatology, Peking University, #22 Zhongguancun South Road, Haidian District, Beijing, 100081, People’s Republic of China

    Xiaowen Zheng, Jieni Zhang & Jiuxiang Lin

  2. Central Laboratory, School of Stomatology, Peking University, Beijing, 100081, People’s Republic of China

    Feng Chen & Qian Zhang

Authors
  1. Xiaowen Zheng
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  2. Feng Chen
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  3. Jieni Zhang
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  4. Qian Zhang
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  5. Jiuxiang Lin
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Corresponding author

Correspondence to Jiuxiang Lin.

Additional information

Xiaowen Zheng and Feng Chen have contributed equally to this paper.

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Zheng, X., Chen, F., Zhang, J. et al. Exosome Analysis: A Promising Biomarker System with Special Attention to Saliva. J Membrane Biol 247, 1129–1136 (2014). https://doi.org/10.1007/s00232-014-9717-1

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  • DOI: https://doi.org/10.1007/s00232-014-9717-1

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