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Serum Levels of Trace Elements and Heavy Metals in Patients with Acute Hemorrhagic Stroke

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Abstract

Trace elements are essential components of biological structures, but alternatively, they can be toxic at concentrations beyond those necessary for their biological functions. Changes in the concentration of essential trace elements and heavy metals may affect acute hemorrhagic stroke. The aim of this study was to measure serum levels of essential trace elements [iron (Fe), zinc (Zn), manganese (Mn), copper (Cu), and magnesium (Mg)] and heavy metals [cobalt (Co), cadmium (Cd), and lead (Pb)] in patients with acute hemorrhagic stroke. Twenty-six patients with acute hemorrhagic stroke and 29 healthy controls were enrolled. Atomic absorption spectrophotometry (UNICAM-929) was used to measure serum Fe, Cu, Pb, Cd, Zn, Co, Mn and Mg concentrations. Serum Cd, Pb and Fe levels were significantly higher in patients with acute hemorrhagic stroke than controls (p < 0.001), while serum Cu, Zn, Mg and Mn levels were significantly lower (all p < 0.001). However, there was no significant difference between the groups with respect to serum Co levels (p > 0.05). We first demonstrate increased Cd, Pb, and Fe levels; and decreased Cu, Zn, Mg, and Mn levels in patients with acute hemorrhagic stroke. These findings may have diagnostic and prognostic value for acute hemorrhagic stroke. Further studies are required to elucidate the roles of trace elements and heavy metals in patients with acute hemorrhagic stroke.

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Authors and Affiliations

  1. Department of Emergency Medicine, Medical Faculty, Yuzuncu Yıl University, Van, Turkey

    Sevdegul Karadas & Hayriye Gonullu

  2. Department of Neurology, Medical Faculty, Yuzuncu Yıl University, Van, Turkey

    Refah Sayın

  3. Department of Internal Medicine, Medical Faculty, Yuzuncu Yıl University, 65000, Van, Turkey

    Mehmet Aslan

  4. Department of Emergency Medicine, Ondokuz Mayıs University, Samsun, Turkey

    Celal Katı & Latif Duran

  5. Department of Emergency Medicine, Van Training Education and Research Hospital, Van, Turkey

    Recep Dursun

  6. Department of Anesthesiology and Reanimation, Van Training Education and Research Hospital, Van, Turkey

    Edip Gonullu

  7. Department of Chemistry, Faculty of Science and Art, Yuzuncu Yıl University, Van, Turkey

    Halit Demir

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  1. Sevdegul Karadas
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Correspondence to Sevdegul Karadas.

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Karadas, S., Sayın, R., Aslan, M. et al. Serum Levels of Trace Elements and Heavy Metals in Patients with Acute Hemorrhagic Stroke. J Membrane Biol 247, 175–180 (2014). https://doi.org/10.1007/s00232-013-9621-0

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  • DOI: https://doi.org/10.1007/s00232-013-9621-0

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