Overview
This review considers the “tween twixt and twain” of hair cell physiology, specifically the signaling elements and membrane conductances which underpin forward and reverse transduction at the input stage of hair cell function and neurotransmitter release at the output stage. Other sections of this review series outline the advances which have been made in understanding the molecular physiology of mechanoelectrical transduction and outer hair cell electromotility. Here we outline the contributions of a considerable array of ion channels and receptor signaling pathways that define the biophysical status of the sensory hair cells, contributing to hair cell development and subsequently defining the operational condition of the hair cells across the broad dynamic range of physiological function.
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References
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Acknowledgement
This work was supported by National Institutes of Health Grants DC07592 and DC03828 (E.N.Y.), and the Royal Society of New Zealand (James Cook Fellowship, G.D.H.). W.M is a Royal Society University Research Fellow.
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An erratum to this article is available at http://dx.doi.org/10.1007/s00232-008-9109-5.
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Housley, G., Marcotti, W., Navaratnam, D. et al. Hair Cells – Beyond the Transducer. J Membrane Biol 209, 89–118 (2006). https://doi.org/10.1007/s00232-005-0835-7
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DOI: https://doi.org/10.1007/s00232-005-0835-7