Skip to main content

Advertisement

Log in

Organization of Golgi Glycosyltransferases in Membranes: Complexity via Complexes

  • Topical Review
  • Published:
The Journal of Membrane Biology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1.
Figure 2.
Fig. 3.
Fig. 4.

References

  • K. Angata T.Y. Yen A. El Battari B.A. Macher M. Fukuda (2001) ArticleTitleUnique disulfide bond structures found in ST8Sia IV polysialyltransferase are required for its activity J. Biol. Chem. 276 15369–15377 Occurrence Handle10.1074/jbc.M100576200 Occurrence Handle11279095

    Article  PubMed  Google Scholar 

  • E.G. Berger (2002) ArticleTitleEctopic localizations of Golgi glycosyltransferases Glycobiology 12 29R–36R Occurrence Handle10.1093/glycob/12.2.29R Occurrence Handle11886838

    Article  PubMed  Google Scholar 

  • E. Bieberich S. MacKinnon J. Silva D.D. Li T. Tencomnao L. Irwin D. Kapitonov R.K. Yu (2002) ArticleTitleRegulation of ganglioside biosynthesis by enzyme complex formation of glycosyltransferases Biochemistry 41 11479–11487 Occurrence Handle10.1021/bi0259958 Occurrence Handle12234191

    Article  PubMed  Google Scholar 

  • E. Bieberich T. Tencomnao D. Kapitonov R.K. Yu (2000) ArticleTitleEffect of N-glycosylation on turnover and subcellular distribution of N-acetylgalactosaminyltransferase I and sialyltransferase II in neuroblastoma cells J. Neurochem. 74 2359–2364 Occurrence Handle10.1046/j.1471-4159.2000.0742359.x Occurrence Handle10820196

    Article  PubMed  Google Scholar 

  • L. Borsig A.G. Katopodis B.R. Bowen E.G. Berger (1998) ArticleTitleTrafficking and localization studies of recombinant α1,3-fucosyltransferase VI stably expressed in CHO cells Glycobiology 8 259–268 Occurrence Handle10.1093/glycob/8.3.259 Occurrence Handle9451035

    Article  PubMed  Google Scholar 

  • M.S. Bretscher S. Munro (1993) ArticleTitleCholesterol and the Golgi apparatus Science 261 1280–1281 Occurrence Handle8362242

    PubMed  Google Scholar 

  • S.J. Charnock G.J. Davies (1999) ArticleTitleStructure of the nucleotide-diphospho-sugar transferase, SpsA from Bacillus subtilis, in native and nucleotide-complexed forms Biochemistry 38 6380–6385 Occurrence Handle10.1021/bi990270y Occurrence Handle10350455

    Article  PubMed  Google Scholar 

  • C. Chen J.Y. Ma A. Lazic M. Backovic K.J. Colley (2000a) ArticleTitleFormation of insoluble oligomers correlates with ST6Gal I stable localization in the Golgi J. Biol. Chem. 275 13819–13826 Occurrence Handle10.1074/jbc.275.18.13819

    Article  Google Scholar 

  • X. Chen Z. Liu J. Wang J. Fang H. Fan P.G. Wang (2000b) ArticleTitleChanging the donor cofactor of bovine alpha 1,3-galactosyltransferase by fusion with UDP-galactose 4-epimerase: More efficient biocatalysis for synthesis of alpha-Gal epitopes J. Biol. Chem. 275 31594–31600 Occurrence Handle10.1074/jbc.M004005200

    Article  Google Scholar 

  • S.K. Cho R.D. Cummings (1997) ArticleTitleA soluble form of alpha1,3-galactosyltransferase functions within cells to galactosylate glycoproteins J. Biol. Chem. 272 13622–13628 Occurrence Handle10.1074/jbc.272.21.13622 Occurrence Handle9153211

    Article  PubMed  Google Scholar 

  • S.K. Cho J.C. Yeh R.D. Cummings (1997) ArticleTitleSecretion of α1,3-galactosyltransferase by cultured cells and presence of enzyme in animal sera Glycoconjugate J. 14 809–819 Occurrence Handle10.1023/A:1018533804015

    Article  Google Scholar 

  • H. Clausen E.P. Bennett (1996) ArticleTitleA family of UDP-GalNAc: Polypeptide N-acetylgalactosaminyl-transferases control the initiation of mucin-type O-linked glycosylation Glycobiology 6 635–646 Occurrence Handle8922959

    PubMed  Google Scholar 

  • N.B. Cole C.L. Smith N. Sciaky M. Terasaki M. Edidin J. Lippincott-Schwartz (1996) ArticleTitleDiffusional mobility of Golgi proteins in membranes of living cells Science 273 797–801 Occurrence Handle8670420

    PubMed  Google Scholar 

  • K.J. Colley (1997) ArticleTitleGolgi localization of glycosyltransferases: More questions than answers Glycobiology 7 1–13 Occurrence Handle9061359

    PubMed  Google Scholar 

  • T. Correia V. Papayannopoulos V. Panin P. Woronoff J. Jiang T.F. Vogt K.D. Irvine (2003) ArticleTitleMolecular genetic analysis of the glycosyltransferase Fringe in Drosophila Proc. Natl. Acad. Sci. USA 100 6404–6409 Occurrence Handle10.1073/pnas.1131007100 Occurrence Handle12743367

    Article  PubMed  Google Scholar 

  • G. D’Agostaro B. Bendiak M. Tropak (1989) ArticleTitleCloning of cDNA encoding the membrane-bound form of bovine beta 1,4-galactosyltransferase Eur. J. Biochem. 183 211–217 Occurrence Handle10.1111/j.1432-1033.1989.tb14915.x Occurrence Handle2502398

    Article  PubMed  Google Scholar 

  • J.L. Daniotti J.A. Martina C.G. Giraudo A.R. Zurita H.J.F. Maccioni (2000) ArticleTitleGM3 alpha 2,8-sialyltransferase (GD3 synthase): Protein characterization and sub-Golgi location in CHO-K1 cells J. Neurochem. 74 1711–1720 Occurrence Handle10.1046/j.1471-4159.2000.0741711.x Occurrence Handle10737630

    Article  PubMed  Google Scholar 

  • C.L. Graffenried ParticleDe C.R. Bertozzi (2003) ArticleTitleGolgi localization of carbohydrate sulfotransferases is a determinant of L-selectin ligand biosynthesis J. Biol. Chem. 278 40282–40295 Occurrence Handle10.1074/jbc.M304928200 Occurrence Handle12855678

    Article  PubMed  Google Scholar 

  • S. Donadio C. Dubois G. Fichant L. Roybon J.C. Guillemot C. Breton C. Ronin (2003) ArticleTitleRecognition of cell surface acceptors by two human alpha-2,6-sialyltransferases produced in CHO cells Biochimie 85 311–321 Occurrence Handle10.1016/S0300-9084(03)00080-4 Occurrence Handle12770770

    Article  PubMed  Google Scholar 

  • M. Elsner H. Hashimoto T. Nilsson (2003) ArticleTitleCisternal maturation and vesicle transport: join the band wagon! Mol. Membr. Biol. 20 221–229 Occurrence Handle10.1080/0968768031000114024 Occurrence Handle12893530

    Article  PubMed  Google Scholar 

  • C.J. Fernández G. Warren (1998) ArticleTitleIn vitro synthesis of sulfated glycosaminoglycans coupled to inter-compartmental Golgi transport J. Biol Chem. 273 19030–19039 Occurrence Handle10.1074/jbc.273.30.19030 Occurrence Handle9668084

    Article  PubMed  Google Scholar 

  • C.G. Giraudo J.L. Daniotti H.J.F. Maccioni (2001) ArticleTitlePhysical and functional association of glycolipid N-acetyl-galactosaminyl and galactosyl transferases in the Golgi apparatus Proc. Natl. Acad. Sci. USA 98 1625–1630 Occurrence Handle10.1073/pnas.031458398 Occurrence Handle11172001

    Article  PubMed  Google Scholar 

  • C.G. Giraudo H.J.F. Maccioni (2003a) ArticleTitleER export of glycosyltransferases depends on interaction of a cytoplasmic di-basic motif with Sar1 Mol. Biol. Cell 14 3753–3766 Occurrence Handle10.1091/mbc.E03-02-0101

    Article  Google Scholar 

  • C.G. Giraudo H.J.F. Maccioni (2003b) ArticleTitleGanglioside glycosyltransferases organize in distinct multienzyme complexes in CHO-K1 cells J. Biol. Chem. 278 40262–40271 Occurrence Handle10.1074/jbc.M305455200

    Article  Google Scholar 

  • V. Girrbach S. Strahl (2003) ArticleTitleMembers of the evolutionarily conserved PMT family of protein O-mannosyltransferases form distinct protein complexes among themselves J. Biol. Chem. 278 12554–12562 Occurrence Handle10.1074/jbc.M212582200 Occurrence Handle12551906

    Article  PubMed  Google Scholar 

  • E. Grabenhorst H.S. Conradt (1999) ArticleTitleThe cytoplasmic, transmembrane, and stem regions of glycosyltransferases specify their in vivo functional sublocalization and stability in the Golgi J. Biol. Chem. 274 36107–36116 Occurrence Handle10.1074/jbc.274.51.36107 Occurrence Handle10593893

    Article  PubMed  Google Scholar 

  • E. Grabenhorst J. Costa H.S. Conradt (1997) Construction of novel BHK-21 cell lines coexpressing Golgi resident or soluble forms of human alpha 2,6-sialyltransferase and alpha 1,3/4-fucosyltransferases together with secretory glycoproteins M.J.T. Carrondo B. Griffiths J.L.P. Moreira (Eds) From Vaccines to Genetic Medicine Kluwer Academic Publishers Dordrecht, The Netherlands 481–487

    Google Scholar 

  • H. Habuchi O. Habuchi K. Kimata (1995) ArticleTitlePurification and characterization of heparan sulfate 6-sulfotransferase from the culture medium of Chinese hamster ovary cells J. Biol. Chem. 270 4172–4179 Occurrence Handle10.1074/jbc.270.8.4172 Occurrence Handle7876170

    Article  PubMed  Google Scholar 

  • S. Hakomori (2002) ArticleTitleThe glycosynapse Proc. Natl Acad. Sci. USA 99 225–232 Occurrence Handle10.1073/pnas.012540899 Occurrence Handle11773621

    Article  PubMed  Google Scholar 

  • J.F. Hare (1990) ArticleTitleMechanisms of membrane protein turnover Biochim. Biophys. Acta 1031 71–90 Occurrence Handle2407292

    PubMed  Google Scholar 

  • A. Helenius E.S. Trombetta D.N. Hebert J.F. Simons (1997) ArticleTitleCalnexin, calreticulin and the folding of glycoproteins Trends Cell Biol. 7 193–200 Occurrence Handle10.1016/S0962-8924(97)01032-5

    Article  Google Scholar 

  • T.R. Henion B.A. Macher F. Anaraki U. Galili (1994) ArticleTitleDefining the minimal size of catalytically active primate α1,3 galactosyltransferase: Structure-function studies on the recombinant truncated enzyme Glycobiology 4 193–202 Occurrence Handle8054718

    PubMed  Google Scholar 

  • F.L. Homa T. Hollander D.J. Lehman D.R. Thomsen A.P. Elhammer (1993) ArticleTitleIsolation and expression of a cDNA clone encoding a bovine UDP-GalNAc:polypeptide N-Acetylgalactosaminyltransferase J. Biol. Chem. 268 12609–12616 Occurrence Handle7685345

    PubMed  Google Scholar 

  • D.E. Humphries B.M. Sullivan M.D. Aleixo J.L. Stow (1997) ArticleTitleLocalization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase to the trans-Golgi network Biochem. J. 325 351–357 Occurrence Handle9230113

    PubMed  Google Scholar 

  • E. Jaskiewicz G. Zhu R. Bassi D.S. Darling W.W. Young SuffixJr. (1996) ArticleTitlebeta-1,4 N-acetylgalactosaminyltransferase (GM2 synthase) is released from Golgi membranes as a neuraminidase sensitive, disulfide-bonded dimer by a cathepsin D-like protease J. Biol. Chem. 271 26395–26403 Occurrence Handle10.1074/jbc.271.42.26430 Occurrence Handle8824296

    Article  PubMed  Google Scholar 

  • D. Jeckel A. Karrenbauer K.N.J. Burger G. Meer ParticleVan F. Wieland (1992) ArticleTitleGlucosylceramide is synthesized at the cytosolic surface of various Golgi subtractions J. Cell. Biol. 117 259–267 Occurrence Handle10.1083/jcb.117.2.259 Occurrence Handle1532799

    Article  PubMed  Google Scholar 

  • T. Ju K. Brewer A. D’Souza R.D. Cummings W.M. Canfield (2002a) ArticleTitleCloning and expression of human core 1 beta1,3-galactosyltransferase J. Biol. Chem. 277 178–186 Occurrence Handle10.1074/jbc.M109060200

    Article  Google Scholar 

  • T. Ju R.D. Cummings (2002) ArticleTitleA unique molecular chaperone Cosmc required for activity of the mammalian core 1 beta 3-galactosyltransferase Proc. Natl. Acad. Sci. USA 99 16613–16618 Occurrence Handle10.1073/pnas.262438199 Occurrence Handle12464682

    Article  PubMed  Google Scholar 

  • T. Ju R.D. Cummings W.M. Canfield (2002b) ArticleTitlePurification, characterization, and subunit structure of rat core 1 Beta1,3-galactosyltransferase J. Biol. Chem. 277 169–177 Occurrence Handle10.1074/jbc.M109056200

    Article  Google Scholar 

  • J. Jungmann S. Munro (1998) ArticleTitleMulti-protein complexes in the cis Golgi of Saccharomyces cerevisiae with α-1,6-mannosyltransferase activity EMBO J. 17 423–434 Occurrence Handle10.1093/emboj/17.2.423 Occurrence Handle9430634

    Article  PubMed  Google Scholar 

  • J. Jungmann J.C. Rayner S. Munro (1999) ArticleTitleThe Saccharomyces cerevisiae protein Mnn10p/Bed1p is a subunit of a Golgi mannosyltransferase complex J. Biol. Chem. 274 6579–6585 Occurrence Handle10.1074/jbc.274.10.6579 Occurrence Handle10037752

    Article  PubMed  Google Scholar 

  • S. Kijimoto-Ochiai N. Yokosawa A. Makita (1980) ArticleTitleMechanism for the biosynthesis of Forssman glycolipid from trihexosylceramide J. Biol. Chem. 255 9037–9040 Occurrence Handle6773959

    PubMed  Google Scholar 

  • H. Kitagawa H. Shimakawa K. Sugahara (1999) ArticleTitleThe tumor suppressor EXT-like gene EXTL2 encodes an alpha1,4-N-acetylhexosaminyltransferase that transfers N-acetylgalactosamine and N-acetylglucosamine to the common glycosaminoglycan-protein linkage region. The key enzyme for the chain initiation of heparan sulfate J. Biol. Chem. 274 13933–13937 Occurrence Handle10.1074/jbc.274.20.13933 Occurrence Handle10318803

    Article  PubMed  Google Scholar 

  • S. Kitazume Y. Tachida R. Oka N. Kotani K. Ogawa M. Suzuki N. Dohmae K. Takio T.C. Saido Y. Hashimoto (2003) ArticleTitleCharacterization of alpha 2,6-sialyltransferase cleavage by Alzheimer’s beta-secretase (BACE1) J. Biol. Chem. 278 14865–14871 Occurrence Handle10.1074/jbc.M206262200 Occurrence Handle12473667

    Article  PubMed  Google Scholar 

  • R. Kleene E.G. Berger (1993) ArticleTitleThe molecular and cell biology of glycosyltransferases Biochim. Biophys. Acta Rev. Biomembr. 1154 283–325 Occurrence Handle10.1016/0304-4157(93)90003-7

    Article  Google Scholar 

  • S. Kornfeld R. Kornfeld (1985) ArticleTitleAssembly of asparagine-linked oligosaccharides Annu. Rev. Biochem. 54 631–664 Occurrence Handle10.1146/annurev.bi.54.070185.003215 Occurrence Handle3896128

    Article  PubMed  Google Scholar 

  • J. Lanoix J. Ouwendijk C.C. Lin A. Stark H.D. Love J. Ostermann T. Nilsson (1999) ArticleTitleGTP hydrolysis by arf-1 mediates sorting and concentration of Golgi resident enzymes into functional COPI vesicles EMBO J. 18 4935–4948 Occurrence Handle10.1093/emboj/18.18.4935 Occurrence Handle10487746

    Article  PubMed  Google Scholar 

  • R.D. Larsen L.K. Ernst R.P. Nair J.B. Lowe (1990) ArticleTitleMolecular cloning, sequence, and expression of a human GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase cDNA that can form the H blood group antigen Proc. Natl. Acad. Sci. USA 87 6674–6678 Occurrence Handle2118655

    PubMed  Google Scholar 

  • J. Li T.-Y. Yen M.L. Allende R.K. Joshi J. Cai W.M. Pierce E. Jaskiewicz D.S. Darling B.A. Macher W.W. Young SuffixJr. (2000) ArticleTitleDisulfide bonds of GM2 synthase homodimers: Antiparallel orientation of the catalytic domains J. Biol. Chem. 275 41476–41486 Occurrence Handle10.1074/jbc.M007480200 Occurrence Handle11018043

    Article  PubMed  Google Scholar 

  • T. Lind F. Tufaro C. McCormick U. Lindahl K. Lidholt (1998) ArticleTitleThe putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate J. Biol. Chem. 273 26265–26268 Occurrence Handle10.1074/jbc.273.41.26265 Occurrence Handle9756849

    Article  PubMed  Google Scholar 

  • J. Ma R. Qian F.M. Rausa SuffixIII. K.J. Colley (1997) ArticleTitleTwo naturally occurring α2,6-sialyltransferase forms with a single amino acid change in the catalytic domain differ in their catalytic activity and proteolytic processing J. Biol. Chem. 272 672–679 Occurrence Handle10.1074/jbc.272.1.672 Occurrence Handle8995311

    Article  PubMed  Google Scholar 

  • J.Y. Ma K.J. Colley (1996) ArticleTitleA disulfide-bonded dimer of the Golgi β-galactoside α2,6-sialyltransferase is catalytically inactive yet still retains the ability to bind galactose J. Biol. Chem. 271 7758–7766 Occurrence Handle10.1074/jbc.271.13.7758 Occurrence Handle8631818

    Article  PubMed  Google Scholar 

  • H.J. Maccioni C.G. Giraudo J.L. Daniotti (2002) ArticleTitleUnderstanding the stepwise synthesis of glycolipids Neurochem. Res. 27 629–636 Occurrence Handle10.1023/A:1020271932760 Occurrence Handle12374198

    Article  PubMed  Google Scholar 

  • C.E. Machamer (2001) ArticleTitleGolgi retention signals: Do membranes hold the key? Trends Cell Biol. 1 141–144 Occurrence Handle10.1016/0962-8924(91)90001-P

    Article  Google Scholar 

  • E.C. Mandon E.S. Kempner M. Ishihara C.B. Hirschberg (1994) ArticleTitleA monomeric protein in the Golgi membrane catalyzes both N-deacetylation and N-sulfation of heparan sulfate J. Biol. Chem. 269 11729–11733 Occurrence Handle8163470

    PubMed  Google Scholar 

  • K.A. Masri H.E. Appert M.N. Fukuda (1988) ArticleTitleIdentification of the full-length coding sequence for human galactosyltransferase (beta-n-acetyglucosaminide: Beta1, 4-galactosyltransferase) Biochem. Biophys. Res. Commun. 157 657–663 Occurrence Handle10.1016/S0006-291X(88)80300-0 Occurrence Handle3144273

    Article  PubMed  Google Scholar 

  • C. McCormick G. Duncan K.T. Goutsos F. Tufaro (2000) ArticleTitleThe putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate Proc. Natl. Acad. Sci. USA 97 668–673 Occurrence Handle10.1073/pnas.97.2.668 Occurrence Handle10639137

    Article  PubMed  Google Scholar 

  • S. Munro (1995) ArticleTitleAn investigation of the role of transmembrane domains in Golgi protein retention EMBO J. 19 4695–4704

    Google Scholar 

  • S. Munro H.R.B. Pelham (1987) ArticleTitleA C-terminal signal prevents secretion of luminal ER proteins Cell 48 899–907 Occurrence Handle10.1016/0092-8674(87)90086-9 Occurrence Handle3545499

    Article  PubMed  Google Scholar 

  • N. Navaratnam S. Ward C. Fisher N.J. Kuhn J.N. Keen J.B.C. Findlay (1988) ArticleTitlePurification, properties and cation activation of galactosyltransferase from lactating-rat mammary Golgi membranes Eur. J. Biochem. 171 623–629 Occurrence Handle10.1111/j.1432-1033.1988.tb13833.x Occurrence Handle3126067

    Article  PubMed  Google Scholar 

  • T. Nilsson M.H. Hoe P. Slusarewicz C. Rabouille R. Watson F. Hunte G. Watzele E.G. Berger G. Warren (1994) ArticleTitleKin recognition between medial Golgi enzymes in HeLa cells EMBO J. 13 562–574 Occurrence Handle8313901

    PubMed  Google Scholar 

  • T. Nilsson C. Rabouille N. Hui R. Watson G. Warren (1996) ArticleTitleThe role of the membrane-spanning domain and stalk region of N-acetylglucosaminyltransferase I in retention, kin recognition and structural maintenance of the Golgi apparatus in HeLa cells J. Cell Sci. 109 1975–1989 Occurrence Handle8832420

    PubMed  Google Scholar 

  • T. Nilsson P. Slusarewicz M.H. Hoe G. Warren (1993) ArticleTitleKin recognition: A model for the retention of Golgi enzymes FEBS Lett. 330 1–4 Occurrence Handle10.1016/0014-5793(93)80906-B Occurrence Handle8370450

    Article  PubMed  Google Scholar 

  • A.S. Opat F. Houghton P.A. Gleeson (2000) ArticleTitleMedial Golgi but not late Golgi glycosyltransferases exist as high molecular weight complexes - Role of luminal domain in complex formation and localization J. Biol. Chem. 275 11836–11845 Occurrence Handle10.1074/jbc.275.16.11836 Occurrence Handle10766809

    Article  PubMed  Google Scholar 

  • A.S. Opat C. Vliet Particlevan P.A. Gleeson (2001) ArticleTitleTrafficking and localisation of resident Golgi glycosylation enzymes Biochimie 83 763–773 Occurrence Handle10.1016/S0300-9084(01)01312-8 Occurrence Handle11530209

    Article  PubMed  Google Scholar 

  • M. Ouzzine S. Gulberti P. Netter J. Magdalou S. Fournel-Gigleux (2000) ArticleTitleStructure-function of the human Gal beta 1,3-glucuronosyltransferase (GlcAT-I). Dimerization and functional activity are mediated by two crucial cysteine residues J. Biol. Chem. 275 28254–28260 Occurrence Handle10842173

    PubMed  Google Scholar 

  • M.A.S. Pinhal B. Smith S. Olson J. Aikawa K. Kimata J.D. Esko (2001) ArticleTitleEnzyme interactions in heparan sulfate biosynthesis: Uronosyl 5-epimerase and 2-O-sulfotransferase interact in vivo Proc. Natl. Acad. Sci. USA 98 12984–12989 Occurrence Handle10.1073/pnas.241175798 Occurrence Handle11687650

    Article  PubMed  Google Scholar 

  • R. Qian C. Chen K.J. Colley (2001) ArticleTitleLocation and mechanism of alpha 2,6-sialyltransferase dimer formation. Role of cysteine residues in enzyme dimerization, localization, activity, and processing J. Biol. Chem. 216 28641–28649 Occurrence Handle10.1074/jbc.M103664200

    Article  Google Scholar 

  • C. Rabouille N. Hui F. Hunte R. Kieckbusch E.G. Berger G. Warren T. Nilsson (1995) ArticleTitleMapping the distribution of Golgi enzymes involved in the construction of complex oligosaccharides J. Cell Sci. 109 1617–1627

    Google Scholar 

  • V.M. Rosales Fritz J.L. Daniotti H.J.F. Maccioni (1997) ArticleTitleChinese hamster ovary cells lacking GM1 and GD1a synthesize gangliosides upon transfection with human GM2 synthase Biochim. Biophys. Acta Gene Struct. Expression 1354 153–158 Occurrence Handle10.1016/S0167-4781(97)00117-6

    Article  Google Scholar 

  • S. Roseman (1970) ArticleTitleThe synthesis of complex carbohydrates by multiglycosyltransferase systems and their potential function in intercellular adhesion Chem. Phys. Lipids 48 270–297 Occurrence Handle10.1016/0009-3084(70)90024-1

    Article  Google Scholar 

  • J. Roth D.J. Taatjes J. Weinstein J.C. Paulson P. Greenwell W.M. Watkins (1986) ArticleTitleDifferential subcompartmentation of terminal glycosylation in the Golgi apparatus of intestinal absorptive and goblet cells J. Biol. Chem. 261 14307–14312 Occurrence Handle3095318

    PubMed  Google Scholar 

  • J. Roth Y. Wang A.E. Eckhardt R.L. Hill (1994) ArticleTitleSubcellular localization of the UDP-N-acetyl-D-galactosamine: Polypeptide N-acetylgalactosaminyltransferase-mediated O-glycosylation reaction in the submaxillary gland Proc. Natl. Acad. Sci. USA 91 8935–8939 Occurrence Handle8090748

    PubMed  Google Scholar 

  • S. Rottger J. White H. Wandall J.C. Olivo A. Stark E. Bennett C. Whitehouse E. Berger H. Clausen T. Nilsson (1998) ArticleTitleLocalization of three human polypeptide GalNAc-transferases in HeLa cells suggests initiation of O-linked glycosylation throughout the Golgi apparatus J. Cell Sci. 111 45–60 Occurrence Handle9394011

    PubMed  Google Scholar 

  • K. Sasai Y. Ikeda T. Tsuda H. Ihara H. Korekane K. Shiota N. Taniguchi (2001) ArticleTitleThe critical role of the stem region as a functional domain responsible for the oligomerization and Golgi localization of N-acetylglucosaminyltransferase V - The involvement of a domain homophilic interaction J. Biol. Chem. 276 759–765 Occurrence Handle10.1074/jbc.M004972200 Occurrence Handle11024048

    Article  PubMed  Google Scholar 

  • M.-P. Schutze P.A. Peterson M.R. Jackson (1994) ArticleTitleAn N-terminal double-arginine motif maintains type II membrane proteins in the endoplasmic reticulum EMBO J. 13 1696–1705 Occurrence Handle8157008

    PubMed  Google Scholar 

  • M. Sekine Y. Hashimoto M. Suzuki F. Inagaki K. Takio A. Suzuki (1994) ArticleTitlePurification and characterization of UDP-GlcNAc:IV3 beta Gal-Gb4Cer beta-1,6-GlcNAc transferase from mouse kidney J. Biol. Chem. 269 31143–31148 Occurrence Handle7983056

    PubMed  Google Scholar 

  • A.D. Simmons M.M. Musy C.S. Lopes L.Y. Hwang Y.P. Yang M. Lovett (1999) ArticleTitleA direct interaction between EXT proteins and glycosyltransferases is defective in hereditary multiple exostoses Hum. Mol. Genet. 8 2155–2164 Occurrence Handle10.1093/hmg/8.12.2155 Occurrence Handle10545594

    Article  PubMed  Google Scholar 

  • E.R. Sjoberg A. Varki (1993) ArticleTitleKinetic and spatial interrelationships between ganglioside glycosyltransferases and O-acetyltransferase(s) in human melanoma cells J. Biol. Chem. 268 10185–10196 Occurrence Handle8486686

    PubMed  Google Scholar 

  • V.L. Sousa C. Brito T. Costa J. Lanoix T. Nilsson J. Costa (2003) ArticleTitleImportance of Cys, Gln, and Tyr from the transmembrane domain of human alpha 3/4 fucosyltransferase III for its localization and sorting in the Golgi of baby hamster kidney cells J. Biol. Chem. 278 7624–7629 Occurrence Handle10.1074/jbc.M209325200 Occurrence Handle12493760

    Article  PubMed  Google Scholar 

  • J. Stolz S. Munro (2002) ArticleTitleThe components of the Saccharomyces cerevisiae mannosyltransferase complex M-Pol I have distinct functions in mannan synthesis J. Biol. Chem. 277 44801–44808 Occurrence Handle10.1074/jbc.M208023200 Occurrence Handle12235155

    Article  PubMed  Google Scholar 

  • G.J. Strous (1986) ArticleTitleGolgi and secreted galactosyltransferase CRC Crit. Rev. Biochem. 21 119–151 Occurrence Handle3093147

    PubMed  Google Scholar 

  • K.G. Ten Hagen T.A. Fritz L.A. Tabak (2003) ArticleTitleAll in the family: the UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferases Glycobiology 13 1R–16R Occurrence Handle10.1093/glycob/cwg007 Occurrence Handle12634319

    Article  PubMed  Google Scholar 

  • C. Vliet Particlevan E.C. Thomas A. Merino-Trigo R.D. Teasdale P.A. Gleeson (2003) ArticleTitleIntracellular sorting and transport of proteins Prog. Biophys. Mol. Biol. 83 1–45 Occurrence Handle10.1016/S0079-6107(03)00019-1 Occurrence Handle12757749

    Article  PubMed  Google Scholar 

  • A. Varki (1998) ArticleTitleFactors controlling the glycosylation potential of the Golgi apparatus Trends Cell Biol. 8 34–40 Occurrence Handle10.1016/S0962-8924(97)01198-7 Occurrence Handle9695806

    Article  PubMed  Google Scholar 

  • N. Yamaguchi M.N. Fukuda (1995) ArticleTitleGolgi retention mechanism of beta-1,4-galactosyltransferase J. Biol. Chem. 270 12170–12176 Occurrence Handle10.1074/jbc.270.33.19551 Occurrence Handle7744867

    Article  PubMed  Google Scholar 

  • T.Y. Yen B.A. Macher S. Bryson X. Chang I. Tvaroska R. Tse S. Takeshita A.M. Lew A. Datti (2003) ArticleTitleHighly conserved cysteines of mouse core 2 beta 1,6 N-acetylglucosaminyltransferase I form a network of disulfide bonds and include a thiol that affects enzyme activity J. Biol. Chem. 278 45864–45881 Occurrence Handle10.1074/jbc.M303851200 Occurrence Handle12954635

    Article  PubMed  Google Scholar 

  • W.W. Young SuffixJr. M.S. Lutz W.A. Blackburn (1992) ArticleTitleEndogenous glycosphingolipids move to the cell surface at a rate consistent with bulk flow estimates J. Biol. Chem. 267 12011–12015 Occurrence Handle1601871

    PubMed  Google Scholar 

  • Z. Yuan R.D. Teasdale (2002) ArticleTitlePrediction of Golgi Type II membrane proteins based on their transmembrane domains Bioinformatics. 18 1109–1115 Occurrence Handle10.1093/bioinformatics/18.8.1109 Occurrence Handle12176834

    Article  PubMed  Google Scholar 

  • G. Zhu M.L. Allende E. Jaskiewicz R. Qian D.S. Darling C.A. Worth K.J. Colley W.W. Young SuffixJr. (1998) ArticleTitleTwo soluble glycosyltransferases glycosylate less efficiently in vivo than their membrane bound counterparts Glycobiology 8 831–840 Occurrence Handle10.1093/glycob/8.8.831 Occurrence Handle9639544

    Article  PubMed  Google Scholar 

  • G. Zhu E. Jaskiewicz R. Bassi D.S. Darling W.W. Young SuffixJr. (1997) ArticleTitlebeta1,4 N-acetylgalactosaminyltransferase (GM2/GD2/GA2 synthase) forms homodimers in the endoplasmic reticulum: a strategy to test for dimerization of Golgi membrane proteins Glycobiology 7 987–996 Occurrence Handle9363441

    PubMed  Google Scholar 

Download references

Acknowledgments

Studies in the author’s laboratory were supported by NIH grant GM065186. I thank Drs. Steve Ellis, Tim Fritz, Sven Gorr, and Binks Wattenberg for their comments about the manuscript. Because the present review is not exhaustive, I apologize for any relevant papers that could not be mentioned herein.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to W. W. Young Jr.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Young, W.W. Organization of Golgi Glycosyltransferases in Membranes: Complexity via Complexes. J Membrane Biol 198, 1–13 (2004). https://doi.org/10.1007/s00232-004-0656-5

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00232-004-0656-5

Keywords

Navigation