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Oculo-bulbar myasthenia gravis induced by cytokine treatment of a patient with metastasized renal cell carcinoma

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Abstract

Objective: The occurrence of autoimmune diseases or deterioration of pre-existing disorders has recently been described after cytokine treatment. The present report gives evidence for acquired myasthenia gravis induced by externally administered interferon-α and interleukin-2 in a patient with metastasized renal cell carcinoma. Electromyographic investigations did not reveal generalised myasthenia gravis. However, a highly elevated titre of antibodies against the human acetylcholine receptor and a significant improvement in clinical symptoms during therapy with anticholinesterase drugs, combined with a decremental response in electronystagmography, indicated an intermittent mainly oculo-bulbar form of myasthenia gravis.

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Authors and Affiliations

  1. Department of Urology, Technical University of Aachen, Pauwelsstrasse 30, D-52057 Aachen, Germany, , , , , , DE

    D. Rohde & G. Jakse

  2. Department of Neurology, Technical University of Aachen, Aachen, Germany, , , , , , DE

    U. Sliwka

  3. Department of Immunology, Technical University of Aachen, Aachen, Germany, , , , , , DE

    K. Schweizer

Authors
  1. D. Rohde
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  2. U. Sliwka
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  3. K. Schweizer
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  4. G. Jakse
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Received: 9 October 1995/Accepted in revised form: 15 January 1996

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Rohde, D., Sliwka, U., Schweizer, K. et al. Oculo-bulbar myasthenia gravis induced by cytokine treatment of a patient with metastasized renal cell carcinoma. E J Clin Pharmacol 50, 471–473 (1996). https://doi.org/10.1007/s002280050143

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  • DOI: https://doi.org/10.1007/s002280050143

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