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Effect of physical activity on serum concentrations of digoxin and digitoxin

  • PHARMACOKINETICA AND DISPOSITION
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Abstract

Objective: To study the influence of moderate physical activity on serum concentrations of digoxin, digitoxin and albumin.

Methods:

Blood samples were drawn from 10 consecutive mobile patients on digoxin and 12 patients on digitoxin therapy before and following a 10-min walking period. Digitalis serum concentrations were determined by radioimmunoassay, and albumin serum concentrations by laser nephelometry.

Results:

Following physical activity, digoxin serum concentrations dropped immediately to 79% of baseline values and remained significantly decreased for 20 min. Digitoxin concentrations did not change significantly.

Conclusion:

In contrast to digoxin, the effect of physical activity the serum concentration of digitoxin can be disregarded.

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Authors and Affiliations

  1. First Medical Department, Community Hospital Kiel, Chemnitzstrasse 33, D-24116 Kiel, Germany , , , , , , DE

    W. Grille

  2. Department of Anesthesiology, University Hospital Kiel, Kiel, Germany, , , , , , DE

    U. Welter

  3. Ostsee-Klinik, Schönberg i.H., Germany, , , , , , DE

    K. Johnsen & K. D. Kolenda

  4. Second Medical Department, University Hospital Kiel, Kiel, Germany, , , , , , DE

    H. Löffler

Authors
  1. W. Grille
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  2. U. Welter
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  3. K. Johnsen
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  4. K. D. Kolenda
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  5. H. Löffler
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Additional information

Received: 27 September 1995/Accepted in revised form: 14 December 1995

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Grille, W., Welter, U., Johnsen, K. et al. Effect of physical activity on serum concentrations of digoxin and digitoxin. E J Clin Pharmacol 50, 237–239 (1996). https://doi.org/10.1007/s002280050099

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  • DOI: https://doi.org/10.1007/s002280050099

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