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Confounding factors for variation of clozapine plasma levels: drug interactions with proton pump inhibitor or infectious etiologies?

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References

  1. Mookhoek E, Loonen (2004) Retrospective evaluation of the effect of omeprazole on clozapine metabolism. Pharm World Sci 26:180–182

    Article  PubMed  CAS  Google Scholar 

  2. Aronson JK (2006) Clozapine. In: Meyler’s side effects of drugs The international encyclopedia of adverse drug reactions and interactions, 15th edn. Oxford, United Kingdom, pp 823-841

  3. Jaquenoud Sirot E, Knezevic B, Morena GP, Harenberg S, Oneda B, Crettol S et al (2009) ABCB1 and cytochrome P450 polymorphisms: clinical pharmacogenetics of clozapine. J Clin Psychopharmacol 29:319–326

    Article  PubMed  CAS  Google Scholar 

  4. Andersson T, Hassan-Alin M, Hasselgren G, Röhss K (2001) Drug interactions studies with esomeprazole, the (S)-isomer of omeprazole. Clin Pharmacokinet 40(7):523–37

    Article  PubMed  CAS  Google Scholar 

  5. Andersson T, Miners JO, Veronese ME, Tassaneeyakul W, Tassaneeyakul W, Meyer UA et al (1993) Identification of human liver cytochrome P450 isoforms mediating omeprazole metabolism. Br J Clin Pharmacol 36:521–530

    PubMed  CAS  Google Scholar 

  6. Frick A, Kopitz J, Bergemann N (2003) Omeprazole reduces clozapine plasma concentrations: A case report. Pharmacopsychiatry 36:121–12

    Article  PubMed  CAS  Google Scholar 

  7. Haack MJ, Bak ML, Beurskens R, Maes M, Stolk LM, Delespaul PA (2003) Toxic rise of clozapine plasma concentrations in relation to inflammation. Eur Neuropsychopharmacol 13:381–385

    Article  PubMed  CAS  Google Scholar 

  8. Pfuhlmann B, Hiemke C, Unterecker S, Burger R, Schmidtke A, Riederer P et al (2009) Toxic clozapine serum levels during inflammatory reactions. J Clin Psychopharmacol 29:392–394

    Article  PubMed  Google Scholar 

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Correspondence to Haleh Bagheri.

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Wagner, S., Varet-Legros, M.G., Fabre, C. et al. Confounding factors for variation of clozapine plasma levels: drug interactions with proton pump inhibitor or infectious etiologies?. Eur J Clin Pharmacol 67, 533–534 (2011). https://doi.org/10.1007/s00228-010-0925-z

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  • DOI: https://doi.org/10.1007/s00228-010-0925-z

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