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Stimulation of endothelial progenitor cells: a new putative effect of several cardiovascular drugs

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Abstract

The role of vascular endothelium in cardiovascular disorders is well recognized. Mature endothelial cells contribute to the repair of endothelial injury, but they only have a limited capacity to do so. This has led to growing interest and further investigation into circulating endothelial progenitor cells (EPCs) and their role in vascular healing, repair, and postnatal neovascularization. The current perception of vascular health is that of a balance between ongoing injury and resultant vascular repair, mediated at least in part by circulating EPCs. Circulating EPCs play an important role in accelerating endothelialization at areas of vascular damage, and EPC enumeration is a viable strategy for assessing reparative capacity. Recent studies have shown that EPCs are affected both in number and function by several cardiovascular risk factors as well as various cardiovascular disease states, such as hypertension, hypercholesterolemia, and coronary artery disease. The present review summarizes the most relevant studies on the effects of cardiovascular drugs on vascular function and EPCs, focusing on their mechanisms of action.

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Authors and Affiliations

  1. Cardiology Department, Coimbra University Hospital and Medical School, Coimbra, Portugal

    Natália António, Lino Gonçalves & Luís A. Providência

  2. Faculty of Medicine, Institute of Pharmacology and Experimental Therapeutics–Biomedical Institute for Research in Light and Image (IBILI), Coimbra University, Coimbra, Portugal

    Natália António, Rosa Fernandes & Carlos Fontes Ribeiro

  3. Research Laboratory, Heart Unit, Virgen de la Victoria University Hospital, Campus Teatinos s/n, Malaga, Spain

    Noela Rodriguez-Losada, Manuel F. Jiménez-Navarro & Eduardo de Teresa Galván

  4. Flow Cytometry Laboratory, Histocompatibility Center of Coimbra, Coimbra, Portugal

    Artur Paiva

  5. Serviço de Cardiologia, Hospitais da Universidade de Coimbra, Avenida Bissaya Barreto, 3000-076, Coimbra, Portugal

    Natália António

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Correspondence to Natália António.

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António, N., Fernandes, R., Rodriguez-Losada, N. et al. Stimulation of endothelial progenitor cells: a new putative effect of several cardiovascular drugs. Eur J Clin Pharmacol 66, 219–230 (2010). https://doi.org/10.1007/s00228-009-0764-y

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  • DOI: https://doi.org/10.1007/s00228-009-0764-y

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