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Captopril-induced bilateral parotid and submandibular sialadenitis

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Abstract

Two cases of sialadenitis following treatment with captopril are described. In case 1, an upper chest and facial erythema and dryness of the mouth accompanied the swelling of the salivary glands. In case 2, a conjunctival erythema accompanied the sialadenitis. None of the patients had previously used captopril, and, in both cases, the swelling occurred within the first hour after the drug intake; the patients had a complete recovery within a few hours after captopril was withdrawn. It is possible that the reported effect was caused by a type-B idiosyncratic adverse drug reaction.

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Fig. 1
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Notes

  1. During the first hour after the onset of symptoms of stroke, treatment of severe hypertension is problematic, because a precipitous decline in arterial pressure may cause a harmful decrease in local perfusion. The blood pressure thresholds recommended by various consensus panels range to >200 mmHg for systolic pressure and >110 mmHg for diastolic pressure [9]. When anti-hypertensive treatment is indicated, it is advisable to lower the blood pressure gradually, and ACE inhibitors are indicated since they present a lesser probability for unfavourable effects to cerebrovascular haemodynamics than other drugs, such as calcium channel blockers [10]

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Authors and Affiliations

  1. Hospital São Vicente de Paulo, Faculdade de Medicina de Jundiaí, Jundiaí, São Paulo, Brazil

    Rafael Mariano Gislon da Silva

  2. Rua Cel Lica Ramos no. 258, 88508-320, Lages, SC, Brazil

    Rafael Mariano Gislon da Silva

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Correspondence to Rafael Mariano Gislon da Silva.

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Gislon da Silva, R.M. Captopril-induced bilateral parotid and submandibular sialadenitis. Eur J Clin Pharmacol 60, 449–453 (2004). https://doi.org/10.1007/s00228-004-0770-z

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