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Inhibition of Matrix Metalloproteinase-1 by Dichloromethylene Bisphosphonate (Clodronate)

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Abstract.

Interstitial collagenase present in human jaw cyst extract and purified human fibroblast-type collagenase (MMP-1) were both efficiently inhibited in vitro by clodronate, an osteoactive, antiresorptive bisphosphonate. The IC50 of clodronate to inhibit MMP-1 is 150 μM. These findings suggest an extended and hitherto undescribed properties for clodronate/biphosphonates in prevention and treatment of tissue degradation in both bone and soft tissue destructive diseases.

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Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, Institute of Dentistry, University of Helsinki, P.O. Bos 41 (Mannerheimintie 172) FIN-00014, Helsinki; Finland, FI

    O. Teronen & C. Lindqvist

  2. Department of Periodontology, 00014 University of Helsinki, Helsinki, Finland, FI

    Y. Ding & T. Sorsa

  3. Department of Pedodontics and Orthodontics, 00014 University of Helsinki, Helsinki, Finland, FI

    T. Ingman

  4. Department of Medicine, 00014 University of Helsinki, Helsinki, Finland, FI

    Y. T. Konttinen & H. Valleala

  5. Department of Orthopedics and Traumatology, 00014 University of Helsinki, Helsinki, Finland, FI

    S. Santavirta

  6. Department of Anatomy, 00014 University of Helsinki, Helsinki, Finland, FI

    A. Lauhio

  7. Department of Oral and Maxillofacial Surgery and Pathology, 90220 University of Oulu, Oulu, Finland, FI

    T. Salo

Authors
  1. O. Teronen
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  2. Y. T. Konttinen
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  3. C. Lindqvist
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  4. T. Salo
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  5. T. Ingman
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  6. A. Lauhio
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  7. Y. Ding
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  8. S. Santavirta
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  9. H. Valleala
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  10. T. Sorsa
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Additional information

Received: 15 July 1996/Accepted: 10 December 1996

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Teronen, O., Konttinen, Y., Lindqvist, C. et al. Inhibition of Matrix Metalloproteinase-1 by Dichloromethylene Bisphosphonate (Clodronate). Calcif Tissue Int 61, 59–61 (1997). https://doi.org/10.1007/s002239900295

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  • DOI: https://doi.org/10.1007/s002239900295

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