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Rationale for active vitamin D analog therapy in senile osteoporosis

  • Satellite Symposium on New Aspects in Therapy With Active Vitamin D Derivatives May 19, 1996 Amsterdam, The Netherlands
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Conclusion

PTH is a potent endogenous stimulator of bone resorption, and PTH secretion increases with age (i.e., secondary hyperparathyroidism). Accordingly, secondary hyperparathyroidism may contribute to the pathogenesis of senile osteoporosis. We postulate that there is a subgroup of elderly subjects who have elevated serum PTH because of 1,25(OH)2D3 deficiency/resistance or both. We believe that with appropriate vitamin D therapy (vitamin D, 1,25(OH)2D3 or 1α(OH)D3) and adequate calcium, much of the problem associated with secondary hyperparathyroidism seen in the senile osteoporotic patient can be effectively treated.

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Authors and Affiliations

  1. Departments of Medicine and Biochemistry, Loma Linda University and Mineral Metabolism, Jerry L. Pettis Memorial V.A. Medical Center, 11201 Benton Street, 92357, Loma Linda, California, USA

    K. Åkesson, K. -H. W. Lau & D. J. Baylink

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  1. K. Åkesson
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  2. K. -H. W. Lau
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  3. D. J. Baylink
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Åkesson, K., Lau, K.H.W. & Baylink, D.J. Rationale for active vitamin D analog therapy in senile osteoporosis. Calcif Tissue Int 60, 100–105 (1997). https://doi.org/10.1007/s002239900195

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