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Reference Intervals for Bone Histomorphometric Measurements Based on Data from Healthy Premenopausal Women

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Abstract

This study has established the normal reference intervals for bone histomorphometric measurements derived from healthy premenopausal women, which is rarely available. We presented the static and dynamic bone histomorphometric data from trans-iliac bone biopsies in 62 healthy premenopausal women (19 blacks and 43 whites, ages 20–53 years). There were no significant differences in age and BMI between black and white women. Since there was no significant difference in bone remodeling between the two ethnic groups, we pooled data of all 62 premenopausal women to establish normal reference intervals for bone histomorphometry. The results provide normal reference intervals for both static and dynamic histomorphometric variables in cancellous and cortical bone of the ilium. None of the bone remodeling-related variables correlated with age or BMI. This study provides reference intervals for bone histomorphometric measurements in both cancellous and cortical bone of the ilium, which would be helpful in the evaluation of bone health in women.

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Acknowledgements

Research reported in this publication was supported by the National Institutes of Health (AG10381 and AG/AR13918) and the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health (AR062103).

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Authors and Affiliations

  1. Bone and Mineral Research Laboratory, Henry Ford Health System, Detroit, MI, USA

    Shijing Qiu & Sudhaker D. Rao

  2. Department of Public Health Sciences, Henry Ford Health System, Detroit, MI, USA

    George Divine

  3. Division of Endocrinology, Diabetes, and Bone & Mineral Disorders, Henry Ford Health System, Detroit, MI, USA

    Elizabeth Warner & Sudhaker D. Rao

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  1. Shijing Qiu
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  4. Sudhaker D. Rao
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Contributions

Study design: SQ and SR; Acquisition of data: SQ and EW; Data analysis and interpretation: SQ, GD and SR; Original draft: SQ; Review and editing: SQ and SR; Final approval of the version to be published: SQ, GD, EW and SR.

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Correspondence to Shijing Qiu.

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Conflict of interest

Shijing Qiu, George Divine, Elizabeth Warner and Sudhaker Rao declare that they have no conflict of interest.

Ethical Approval

The study was conducted in accordance with the ethical standards of the institutional research committee of Henry Ford Hospital and the 1964 Helsinki Declaration and its later amendments.

Human and Animal Rights and Informed Consent

The study was approved by the Institutional Review Board of Henry Ford Hospital and written informed consent was provided by all the participants.

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Qiu, S., Divine, G., Warner, E. et al. Reference Intervals for Bone Histomorphometric Measurements Based on Data from Healthy Premenopausal Women. Calcif Tissue Int 107, 543–550 (2020). https://doi.org/10.1007/s00223-020-00748-6

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  • DOI: https://doi.org/10.1007/s00223-020-00748-6

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