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Jump Exercise and Food Restriction on Bone Parameters in Young Female Rats

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Abstract

We examined the effect of jump exercise on bone parameters in young female rats under food restriction. Seven-week-old female rats were divided into four groups: a sedentary and ad libitum feeding group (n = 10), a jump exercise and ad libitum feeding group (n = 9), a sedentary and 30% food restriction group (n = 9), and a jump exercise and 30% food restriction group (n = 10). The jump groups jumped 20 times/day, 5 times/week. The experiment lasted for 13 weeks. There were no interactions of jump exercise and food restriction on bone. Jump exercise under food restriction conditions induced higher bone strength, bone mineral content, bone area, bone mineral density (BMD), and cortical bone volume in young female rats, similar to rats under ad libitum feeding conditions. Bone strength parameters were not significantly different between ad libitum intake and food restriction with jump exercise training; however, BMD, bone size, and bone mass in the food restriction groups did not reach the levels of those in the ad libitum conditions group with jump exercise training. Neither jump exercise nor food restriction had a significant effect on serum estradiol or IGF-1. Our study reveals jump exercise attenuates loss of biomechanical properties and some bone sites with food restriction in young female rats.

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Acknowledgements

We thank Dr. Norihiro Yamada for his technical support for animal care and dissection. This work was supported by JSPS KAKENHI Grant Number JP18K17843 and Cooperative Research Grant of Advanced Research Initiative for Human High Performance, University of Tsukuba.

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Authors and Affiliations

  1. Department of Science of Living, Tsu City College, 157 Isshinden-nakano, Tsu, Mie, 514-0112, Japan

    Yuki Aikawa

  2. Faculty of Health Science, Suzuka University of Medical Science, 1001-1 Kishioka, Suzuka, Mie, 510-0293, Japan

    Yusuke Wakasugi, Takahiro Narukawa, Takenori Yamashita, Nobuaki Sasai & Makoto Ohtsuki

  3. School of Health and Sport Sciences, Chukyo University, 101 Tokodachi, Kaizu-cho, Toyota, Aichi, 470-0393, Japan

    Yoshihisa Umemura

  4. Faculty of Health and Sport Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8572, Japan

    Naomi Omi

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  1. Yuki Aikawa
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Correspondence to Yuki Aikawa.

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Human and Animal Rights and Informed Consent

Animal care and experimental procedures were approved by the ethics committe of Suzuka University of Medical Science. All experimental protocols were conducted in accordance with the Guidelines for the Care and Use of Laboratory Animals (approval number: 262).

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Aikawa, Y., Wakasugi, Y., Narukawa, T. et al. Jump Exercise and Food Restriction on Bone Parameters in Young Female Rats. Calcif Tissue Int 105, 557–566 (2019). https://doi.org/10.1007/s00223-019-00601-5

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