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Interactions Between B Lymphocytes and the Osteoblast Lineage in Bone Marrow

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Abstract

The regulatory effects of the immune system on the skeleton during homeostasis and activation have been appreciated for years. In the past decade it has become evident that bone tissue can also regulate immune cell development. In the bone marrow, the differentiation of hematopoietic progenitors requires specific microenvironments, called “niches,” provided by various subsets of stromal cells, many of which are of mesenchymal origin. Among these stromal cell populations, cells of the osteoblast lineage serve a supportive function in the maintenance of normal hematopoiesis, and B lymphopoiesis in particular. Within the osteoblast lineage, distinct differentiation stages exert differential regulatory effects on hematopoietic development. In this review we will highlight the critical role of osteoblast progenitors in the perivascular B lymphocyte niche.

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Acknowledgements

This work was supported by the Harvard Stem Cell Institute (Cambridge, MA) and NIH Grant DP2OD008466 to J. Y.W

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  1. Division of Endocrinology, Gerontology and Metabolism, Stanford University School of Medicine, 300 Pasteur Dr., S-025, Stanford, CA, 94305, USA

    Cristina Panaroni & Joy Y. Wu

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  1. Cristina Panaroni
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Correspondence to Joy Y. Wu.

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Panaroni, C., Wu, J.Y. Interactions Between B Lymphocytes and the Osteoblast Lineage in Bone Marrow. Calcif Tissue Int 93, 261–268 (2013). https://doi.org/10.1007/s00223-013-9753-3

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