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Association between Systemic Calcified Atherosclerosis and Bone Density

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Abstract

Both atherosclerosis and osteoporosis are responsible for significant morbidity and mortality, are independent predictors of cardiovascular disease (CVD) events, and may share common regulatory mechanisms as well as histopathology. Multiple reports of weak or null relationships between traditional CVD risk factors and calcified atherosclerosis have heightened interest in novel predictors of arterial calcium. One such hypothesis is for an inverse relationship between bone mineral density (BMD) and calcified coronary atherosclerosis. Although contrary findings have been reported, the majority of cross-sectional and all prospective studies have demonstrated a significant inverse association between arterial calcium deposits and BMD. The few studies that include men are equivocal, and, to date, no study has investigated the relationship between BMD and systemic arterial calcium. The aim of this study was to test the hypothesis that lumbar BMD is significantly associated with the presence of arterial atherosclerotic calcium in the carotid, coronary, and iliac vascular beds as well as the aorta.

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References

  1. Stafford RS, Drieling RL, Hersh AL (2004) National trends in osteoporosis visits and osteoporosis treatment, 1988–2003. Arch Intern Med 164:1525–1530

    Article  PubMed  Google Scholar 

  2. Kado DM, Browner WS, Blackwell T, Gore R, Cummings SR (2000) Rate of bone loss is associated with mortality in older women: a prospective study. J Bone Miner Res 15:1974–1980

    Article  PubMed  CAS  Google Scholar 

  3. Jorgensen L, Engstad T, Jacobsen BK (2001) Bone mineral density in acute stroke patients: low bone mineral density may predict first stroke in women. Stroke 32:47–51

    PubMed  CAS  Google Scholar 

  4. Tintut Y, Demer LL (2001) Recent advances in multifactorial regulation of vascular calcification. Curr Opin Lipidol 12:555–560

    Article  PubMed  CAS  Google Scholar 

  5. Adami S, Braga V, Zamboni M, Gatti D, Rossini M, Bakri J, Battaglia E (2004) Relationship between lipids and bone mass in 2 cohorts of healthy women and men. Calcif Tissue Int 74:136–142

    Article  PubMed  CAS  Google Scholar 

  6. Mody N, Parhami F, Sarafian TA, Demer LL (2001) Oxidative stress modulates osteoblastic differentiation of vascular and bone cells. Free Radic Biol Med 31:509–519

    Article  PubMed  CAS  Google Scholar 

  7. Demer LL, Tintut Y (2003) Mineral exploration: search for the mechanism of vascular calcification and beyond. The 2003 Jeffrey M. Hoeg Award lecture. Arterioscler Thromb Vasc Biol 23:1739–1743

    Article  PubMed  CAS  Google Scholar 

  8. Taylor AJ, Feuerstein I, Wong H, Barko W, Brazaitis M, O’Malley PG (2001) Do conventional risk factors predict subclinical coronary artery disease? Results from the Prospective Army Coronary Calcium Project. Am Heart J 141:463–468

    Article  PubMed  CAS  Google Scholar 

  9. Allison MA, Wright M, Tiefenbrun J (2003) The predictive power of low-density lipoprotein cholesterol for coronary calcification. Int J Cardiol 90:281–289

    Article  PubMed  Google Scholar 

  10. Doherty TM, Asotra K, Fitzpatrick LA, Qiao JH, Wilkin DJ, Detrano RC, Dunstan CR, Shah PK, Rajavashisth TB (2003) Calcification in atherosclerosis: bone biology and chronic inflammation at the arterial crossroads. Proc Natl Acad Sci USA 100:11201–11206

    Article  PubMed  CAS  Google Scholar 

  11. Aoyagi K, Ross PD, Orloff J, Davis JW, Katagiri H, Wasnich RD (2001) Low bone density is not associated with aortic calcification. Calcif Tissue Int 69:20–24

    Article  PubMed  CAS  Google Scholar 

  12. Drinka PJ, Bauwens SF, DeSmet AA (1992) Lack of correlation between aortic calcification and bone density. Wis Med J 91:299–301

    PubMed  CAS  Google Scholar 

  13. Jorgensen L, Joakimsen O, Rosvold Berntsen GK, Heuch I, Jacobsen BK (2004) Low bone mineral density is related to echogenic carotid artery plaques: a population-based study. Am J Epidemiol 160:549–556

    Article  PubMed  Google Scholar 

  14. Schulz E, Arfai K, Liu X, Sayre J, Gilsanz V (2004) Aortic calcification and the risk of osteoporosis and fractures. J Clin Endocrinol Metab 89:4246–4253

    Article  PubMed  CAS  Google Scholar 

  15. Kiel DP, Kauppila LI, Cupples LA, Hannan MT, O’Donnell CJ, Wilson PW (2001) Bone loss and the progression of abdominal aortic calcification over a 25 year period: the Framingham Heart Study. Calcif Tissue Int 68:271–276

    Article  PubMed  CAS  Google Scholar 

  16. Hak AE, Pols HA, van Hemert AM, Hofman A, Witteman JC (2000) Progression of aortic calcification is associated with metacarpal bone loss during menopause: a population-based longitudinal study. Arterioscler Thromb Vasc Biol 20:1926–1931

    PubMed  CAS  Google Scholar 

  17. Jie KG, Bots ML, Vermeer C, Witteman JC, Grobbee DE (1996) Vitamin K status and bone mass in women with and without aortic atherosclerosis: a population-based study. Calcif Tissue Int 59:352–356

    Article  PubMed  CAS  Google Scholar 

  18. Barengolts EI, Berman M, Kukreja SC, Kouznetsova T, Lin C, Chomka EV (1998) Osteoporosis and coronary atherosclerosis in asymptomatic postmenopausal women. Calcif Tissue Int 62:209–213

    Article  PubMed  CAS  Google Scholar 

  19. Agatston AS, Janowitz WR, Hildner FJ, Zusmer NR, Viamonte M Jr, Detrano R (1990) Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol 15:827–832

    Article  PubMed  CAS  Google Scholar 

  20. McClelland RL, Chung H, Detrano R, Post W, Kronmal RA (2006) Distribution of coronary artery calcium by race, gender, and age: results from the Multi-Ethnic Study of Atherosclerosis (MESA). Circulation 113:30–37

    Article  PubMed  Google Scholar 

  21. Allison MA, Criqui MH, Wright CM (2003) Patterns and risk factors for systemic calcified atherosclerosis. Arterioscler Thromb Vasc Biol 24:331–336

    Article  PubMed  CAS  Google Scholar 

  22. Riggs BL, Khosla S, Melton LJ 3rd (2002) Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev 23:279–302

    Article  PubMed  CAS  Google Scholar 

  23. Doherty TM, Fitzpatrick LA, Inoue D, Qiao JH, Fishbein MC, Detrano RC, Shah PK, Rajavashisth TB (2004) Molecular, endocrine, and genetic mechanisms of arterial calcification. Endocr Rev 25:629–672

    Article  PubMed  CAS  Google Scholar 

  24. Allison MA, Wright CM (2005) Age and gender are the strongest clinical correlates of prevalent coronary calcification. Int J Cardiol 98:325–330

    Article  PubMed  Google Scholar 

  25. Pletcher MJ, Tice JA, Pignone M, Browner WS (2004) Using the coronary artery calcium score to predict coronary heart disease events: a systematic review and meta-analysis. Arch Intern Med 164:1285–1292

    Article  PubMed  Google Scholar 

  26. Greenland P, LaBree L, Azen SP, Doherty TM, Detrano RC (2004) Coronary artery calcium score combined with Framingham score for risk prediction in asymptomatic individuals. JAMA 291:210–215

    Article  PubMed  CAS  Google Scholar 

  27. Kondos GT, Hoff JA, Sevrukov A, Daviglus ML, Garside DB, Devries SS, Chomka EV, Liu K (2003) Electron-beam tomography coronary artery calcium and cardiac events: a 37-month follow-up of 5635 initially asymptomatic low- to intermediate-risk adults. Circulation 107:2571–2576

    Article  PubMed  Google Scholar 

  28. Witteman JC, Kok FJ, van Saase JL, Valkenburg HA (1986) Aortic calcification as a predictor of cardiovascular mortality. Lancet 2:1120–1122

    Article  PubMed  CAS  Google Scholar 

  29. Wilson PW, Kauppila LI, O’Donnell CJ, Kiel DP, Hannan M, Polak JM, Cupples LA (2001) Abdominal aortic calcific deposits are an important predictor of vascular morbidity and mortality. Circulation 103:1529–1534

    PubMed  CAS  Google Scholar 

  30. Bakhireva LN, Barrett-Connor EL, Laughlin GA, Kritz-Silverstein D (2005) Differences in association of bone mineral density with coronary artery calcification in men and women: the Rancho Bernardo Study. Menopause 12:691–698

    Article  PubMed  Google Scholar 

  31. Sinnott B, Syed I, Syed A, Barengolts E (2006) Coronary calcification and osteoporosis in men and postmenopausal women are independent processes associated with aging. Calcif Tissue Int 78:195–202

    Article  PubMed  CAS  Google Scholar 

  32. Uyama O, Yoshimoto Y, Yamamoto Y, Kawai A (1997) Bone changes and carotid atherosclerosis in postmenopausal women. Stroke 28:1730–1732

    PubMed  CAS  Google Scholar 

  33. Kammerer CM, Dualan AA, Samollow PB, Perisse AR, Bauer RL, MacCluer JW, O’Leary DH, Mitchell BD (2004) Bone mineral density, carotid artery intimal medial thickness, and the vitamin D receptor BsmI polymorphism in Mexican American women. Calcif Tissue Int 75:292–298

    Article  PubMed  CAS  Google Scholar 

  34. Reilly MP, Wolfe ML, Localio AR, Rader DJ (2004) Coronary artery calcification and cardiovascular risk factors: impact of the analytic approach. Atherosclerosis 173:69–78

    Article  PubMed  CAS  Google Scholar 

  35. Parhami F, Morrow AD, Balucan J, Leitinger N, Watson AD, Tintut Y, Berliner JA, Demer LL (1997) Lipid oxidation products have opposite effects on calcifying vascular cell and bone cell differentiation. A possible explanation for the paradox of arterial calcification in osteoporotic patients. Arterioscler Thromb Vasc Biol 17:680–687

    PubMed  CAS  Google Scholar 

  36. Parhami F, Basseri B, Hwang J, Tintut Y, Demer LL (2002) High-density lipoprotein regulates calcification of vascular cells. Circ Res 91:570–576

    Article  PubMed  CAS  Google Scholar 

  37. Cappuccio FP, Meilahn E, Zmuda JM, Cauley JA (1999) High blood pressure and bone-mineral loss in elderly white women: a prospective study. Study of Osteoporotic Fractures Research Group. Lancet 354:971–975

    CAS  Google Scholar 

  38. Edmonds ME (2000) Medial arterial calcification and diabetes mellitus. Z Kardiol 89(suppl 2):101–104

    Article  PubMed  Google Scholar 

  39. Raggi P (2005) Cardiovascular calcification in end stage renal disease. Contrib Nephrol 149:272–278

    Article  PubMed  Google Scholar 

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Acknowledgments

This work was supported in part by a grant from the American Heart Association. No authors have any financial disclosures.

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Authors and Affiliations

  1. Department of Family and Preventive Medicine, University of California San Diego, 3855 Health Sciences Drive, MC 0817, La Jolla, CA, 92093-0817, USA

    J. A. Hyder, M. A. Allison & M. H. Criqui

  2. Department of Medicine, University of California San Diego, La Jolla, CA, USA

    M. H. Criqui & C. M. Wright

Authors
  1. J. A. Hyder
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  2. M. A. Allison
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  3. M. H. Criqui
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  4. C. M. Wright
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Correspondence to M. A. Allison.

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Hyder, J.A., Allison, M.A., Criqui, M.H. et al. Association between Systemic Calcified Atherosclerosis and Bone Density. Calcif Tissue Int 80, 301–306 (2007). https://doi.org/10.1007/s00223-007-9004-6

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  • DOI: https://doi.org/10.1007/s00223-007-9004-6

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