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Quantitative Ultrasound Measurements in Children and Adolescents with: Type 1 Diabetes

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Abstract

The aim of the current study was to evaluate bone status at the radius and phalanx in children and adolescents with type 1 diabetes by using quantitative ultrasound (QUS) measurements. Thirty pediatric patients, 16 male and 14 female, with type 1 diabetes of duration of 5 to 177 months and mean (± SD) age 11.3 ± 4.6 years were studied. QUS measurements were carried out using the Sunlight Omnisense 7000 S device. Speed of sound (SOS) was measured at the radius and tibia. Diabetic control was assessed by glycosylated hemoglobin (HbA1c) measurements. Male and female patients with type 1 diabetes did not have significantly different SOS or HbA1c values. SOS Z-scores at both the radius and tibia were negatively associated with duration of disease (r = −0 41 and r = −0.37 for the radius and tibia respectively, P < 0.05 for both correlations). Seven of 15 patients with duration of disease of >6 years had diminished SOS, defined as Z-score of <−1, at either the radius or tibia. SOS measurements at the radius showed moderate correlation with SOS at the tibia (r = 0.58, P < 0.00 l). There was no correlation between SOS and HbA1c. In conclusion, SOS Z-scores at both the radius and tibia show a significant negative correlation with duration of insulin-dependent diabetes in children. No relation was found between SOS and metabolic control of young diabetic patients.

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Authors and Affiliations

  1. Department of Medical Physics, University of Crete, Iraklion, Crete, Greece

    J. Damilakis

  2. Department of Pediatrics, University Hospital of Iraklion, Crete, Greece

    E. Galanakis, D. Mamoulakis & S. Sbyrakis

  3. Department of Radiology, University of Crete, Iraklion, Crete, Greece

    N. Gourtsoyiannis

  4. Department of Medical Physics, University of Crete, Faculty of Medicine, P.O. Box 2208, 71003, Iraklion, Crete, Greece

    J. Damilakis

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  1. J. Damilakis
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  2. E. Galanakis
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  3. D. Mamoulakis
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  4. S. Sbyrakis
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  5. N. Gourtsoyiannis
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Correspondence to J. Damilakis.

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Damilakis, J., Galanakis, E., Mamoulakis, D. et al. Quantitative Ultrasound Measurements in Children and Adolescents with: Type 1 Diabetes. Calcif Tissue Int 74, 424–428 (2004). https://doi.org/10.1007/s00223-003-0164-8

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  • DOI: https://doi.org/10.1007/s00223-003-0164-8

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