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Bone Turnover Markers and PTH Levels in Surgical Versus Natural Menopause

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Abstract

In order to assess similarities and differences in women that suffer surgical versus natural menopause, a series of bone, clinical, and biochemical parameters was assayed in a clinical sample of 35 women with surgical menopause and 112 women with natural menopause. Biochemical parameters included hormones [parathyroid hormone (PTH) and the sex steroids estradiol and testosterone] and several markers of bone turnover measured in urine (N-telopeptide and calcium/creatinine ratio) or serum (osteocalcin, total alkaline phosphatase, total and ionic calcium, phosphate, and magnesium). In addition to type of menopause, women were divided by years since menopause (ysm ≤ 2 or >2). To detect differences and relationships between variables, ANOVA, ANCOVA, and linear regression analyses were used. Only N-telopeptide, one resorption marker, was significantly affected by the variable years since menopause ≤2 or >2 (P <0.01), but not by type of menopause. The age-corrected level of PTH was significantly decreased in the surgical menopause group (P < 0.05). In conclusion, type of menopause did not impose significant differences in bone turnover markers. PTH, one powerful resorption hormone, was diminished in surgical menopause.

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Acknowledgements

The authors are indebted to Mrs. Rosa Aliaga and Mrs. Elvira Calap for their excellent technical assistance. This study has been supported by grants 1FD97-1035-C02-01 from the CICYT and European Union, 00/0960 and 01/3051 from the FIS, and GV99-138-1-04 and GV99-6-1-04 from the Conselleria de Cultura, Educació i Ciència, Generalitat Valenciana.

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Authors and Affiliations

  1. Research Unit, Hospital Clínico Universitario de Valencia, Valencia, Spain

    M. A. García–Pérez

  2. Department of Paediatrics, Obstetrics and Gynaecology, Faculty of Medicine, University of Valencia, Valencia, Spain

    J. Moreno–Mercer & A. Cano

  3. Department of Functional Biology and Physical Anthropology, Faculty of Biological Sciences, University of Valencia, Valencia, Spain

    J. J. Tarín

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  1. M. A. García–Pérez
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  3. J. J. Tarín
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Correspondence to A. Cano.

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García–Pérez, M., Moreno–Mercer, J., Tarín, J. et al. Bone Turnover Markers and PTH Levels in Surgical Versus Natural Menopause . Calcif Tissue Int 74, 143–149 (2004). https://doi.org/10.1007/s00223-003-0054-0

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