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Bone Mineral Density of the Spine and Femur in Early Postmenopausal Turkish Women with Endemic Skeletal Fluorosis

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Abstract

The aim of this prospective, comparative study was to investigate the bone mineral density (BMD) changes in a group of early postmenopausal Turkish women with endemic skeletal fluorosis and to study effects of endemic fluorosis on BMD. Bone mineral density of L2–L4 vertebra, femur neck, femur trochanter, and Ward’s triangle were measured in 45 female patients with endemic skeletal fluorosis and 41 age-matched controls by dual X-ray absorbtiometry (DXA). The BMD of L2–L4 vertebra and Ward’s triangle were higher in the endemic fluorosis group than in the control group (P < 0.001). Patients with endemic fluorosis had higher femur neck and femur trochanter BMDs than did controls (P < 0.01 and P < 0.05, respectively). There was a positive correlation between serum fluoride content and BMD at the spine (r = 0.345, P = 0.001), femoral neck (r = 0.274, P = 0.011), Ward’s triangle (r = 0.295, P = 0.006), and trochanter (r = 0.217, P = 0.045). In conclusion, higher bone mineral density levels were seen in early postmenopausal women with endemic skeletal fluorosis. BMD measurement is a tool in the diagnosis and management of this preventable crippling disease.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Süleyman Demirel University, School of Medicine, Isparta/Turkey

    M. Yıldız

  2. Department of Biochemistry, Süleyman Demirel University, School of Medicine, Isparta/Turkey

    M. Akdoğan

  3. Department of Endocrinology, Süleyman Demirel University, School of Medicine, Isparta/Turkey

    N. Tamer

  4. Department of Obstetric and Gynaecology, Süleyman Demirel University, School of Medicine, Isparta/Turkey

    B. Oral

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  1. M. Yıldız
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  2. M. Akdoğan
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  3. N. Tamer
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  4. B. Oral
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Correspondence to M. Yıldız.

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Yıldız, M., Akdoğan, M., Tamer, N. et al. Bone Mineral Density of the Spine and Femur in Early Postmenopausal Turkish Women with Endemic Skeletal Fluorosis . Calcif Tissue Int 72, 689–693 (2003). https://doi.org/10.1007/s00223-002-2097-z

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