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Frontal theta is a signature of successful working memory manipulation

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Abstract

It has been proposed that working memory (WM) is updated/manipulated via a fronto-basal-ganglia circuit. One way that this could happen is via the synchronization of neural oscillations. A first step toward testing this hypothesis is to clearly establish a frontal scalp EEG signature of WM manipulation. Although many EEG studies have indeed revealed frontal EEG signatures for WM, especially in the theta frequency band (3–8 Hz), few of them required subjects to manipulate WM, and of those that did, none specifically tied the EEG signature to the manipulation process per se. Here we employed a WM manipulation task that has been shown with imaging to engage the prefrontal cortex and the striatum. We adapted this task to titrate the success of WM manipulation to approximately 50 %. Using time–frequency analysis of EEG, we showed that theta power increased over frontal cortex for successful versus failed WM manipulation, specifically at the time of the manipulation event. This establishes a clear-cut EEG signature of WM manipulation. Future studies could employ this to test the fronto-basal-ganglia hypothesis of WM updating/manipulation.

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Acknowledgments

Thanks to Nicole Swann, Paul Sauseng, and Jobi George for discussion. Funding was gratefully received from the Alfred P Sloan Foundation and NIH Grant DA026452.

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Authors and Affiliations

  1. Neurosciences Graduate Program, University of California, San Diego, La Jolla, San Diego, CA, 92093, USA

    Sirawaj Itthipuripat & Adam R. Aron

  2. Department of Psychology, University of California, San Diego, 9500 Gilman Drive, La Jolla, San Diego, CA, 92093, USA

    Jan R. Wessel & Adam R. Aron

Authors
  1. Sirawaj Itthipuripat
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  2. Jan R. Wessel
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  3. Adam R. Aron
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Correspondence to Adam R. Aron.

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Itthipuripat, S., Wessel, J.R. & Aron, A.R. Frontal theta is a signature of successful working memory manipulation. Exp Brain Res 224, 255–262 (2013). https://doi.org/10.1007/s00221-012-3305-3

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