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Unilateral hemispherectomy at adulthood asymmetrically affects motor performance of male Swiss mice

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Abstract

Evidence exists indicating that cerebral lateralization is a fundamental feature of all vertebrates. In humans, a series of studies demonstrated that the left hemisphere plays a major role in controlling movement. No such asymmetries have been identified in rodents, in spite of the fact that these animals have been frequently used in studies assessing motor behavior. In this regard, here, we used unilateral hemispherectomy to study the relative importance of each hemisphere in controlling movement. Adult Swiss mice were submitted to right unilateral hemispherectomy (RH), left unilateral hemispherectomy (LH) or sham surgery. Fifteen days after surgery, motor performance was assessed in the accelerating rotarod test and in the foot-fault test (in which performance depends on skilled limb use) and in the elevated body swing test (in which performance depends on trunk movements). The surgical removal of the right hemisphere caused a more pronounced impairment in performance than the removal of the left hemisphere both in the rotarod and in the foot-fault tests. In the rotarod, the RH group presented smaller latencies to fall than both LH and sham groups. In the foot-fault test, while both the sham and the LH groups showed no differences between left and right hind limbs, the RH group showed significantly worse performance with the left hind limb than with the right one. The elevated body swing test revealed a similar impairment in the two hemispherectomized groups. Our data suggest a major role of the right hemisphere in controlling skilled limb movements in mice.

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Acknowledgments

Funding for this study was provided by Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) and by Sub-reitoria de Pós-graduação e Pesquisa da Universidade do Estado do Rio de Janeiro (SR2-UERJ). DPB receives a FAPERJ M.Sc. fellowship, while Yael Abreu-Villaça, Alex C. Manhães and Cláudio C. Filgueiras are CNPq and FAPERJ research fellows. The authors are thankful to Edson Oliveira and Ulisses Risso Siqueira for animal care.

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  1. Laboratório de Neurofisiologia, Departamento de Ciências Fisiológicas, Instituto Roberto Alcantara Gomes, Centro Biomédico, Universidade do Estado do Rio de Janeiro (UERJ), Avenida Professor Manoel de Abreu 444, 5 andar, Vila Isabel, Rio de Janeiro, RJ, 20550-170, Brazil

    Danielle Paes-Branco, Yael Abreu-Villaça, Alex C. Manhães & Cláudio C. Filgueiras

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  1. Danielle Paes-Branco
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Correspondence to Cláudio C. Filgueiras.

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Paes-Branco, D., Abreu-Villaça, Y., Manhães, A.C. et al. Unilateral hemispherectomy at adulthood asymmetrically affects motor performance of male Swiss mice. Exp Brain Res 218, 465–476 (2012). https://doi.org/10.1007/s00221-012-3034-7

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