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Influence of periodontal afferent inputs for human cerebral blood oxygenation during jaw movements

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Abstract

Using functional magnetic resonance imaging (fMRI) and near-infrared spectroscopy (NIRS), we examined the role of periodontal afferent inputs on cerebral activation pattern evoked by masticatory muscle activity in twenty-two subjects. Statistical comparisons were used to identify brain regions with significant activation after subtraction of baseline activity from sham teeth-tapping (no periodontal input) and teeth-tapping (periodontal input) activity in an fMRI (N = 14) and NIRS study (N = 8). Both sham teeth-tapping and teeth-tapping significantly activated bilateral sensorimotor cortex and supplementary motor area in the fMRI study. NIRS revealed that oxygenated hemoglobin concentrations increased in sensorimotor cortex; however, there was no significant difference in degree of oxygenated hemoglobin changes between sham teeth-tapping and teeth-tapping. A control study (N = 8) characterized the jaw muscle activity and amplitude of the two motor tasks and demonstrated significantly higher electromyogram (EMG) activity in the jaw closing muscles during teeth contact in the teeth-tapping session. Since the cerebral activation during sham teeth-tapping and teeth-tapping was similar, we suggest that the influence of periodontal afferent inputs and associated jaw muscle activity is relatively minor compared to the rhythmic jaw movements. Although the clinical significance of the present findings remains unknown, they may have implications for the understanding of awake or sleep-related bruxism characterized by subconscious and rhythmic teeth-grinding or teeth-clenching.

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Acknowledgments

This study was supported by a grant-in-aid for young scientists (B 21791921) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, and a grant-in-aid for scientific research (C22592164 and C 23592870) from the Japanese Society for the Promotion of Science.

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Authors and Affiliations

  1. Department of Oral Function and Rehabilitation, Nihon University School of Dentistry at Matsudo, 2-870-1, Sakaecho-nishi, Matsudo Chiba, 271-8587, Japan

    Takashi Iida, Osamu Komiyama & Misao Kawara

  2. Department of Clinical Oral Physiology, School of Dentistry, Aarhus University, Aarhus, Denmark

    Takashi Iida & Peter Svensson

  3. Department of Radiology, Nihon University School of Dentistry at Matsudo, Chiba, Japan

    Masashi Sakayanagi & Takashi Kaneda

  4. Center for Functionally Integrative Neuroscience, MindLab, Aarhus University Hospital, Aarhus, Denmark

    Peter Svensson

  5. Department of Neurological Surgery, Nihon University School of Dentistry at Matsudo, Tokyo, Japan

    Teruyasu Hirayama

  6. Division of Optical Brain Engineering, Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan

    Kaoru Sakatani

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  1. Takashi Iida
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  2. Masashi Sakayanagi
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  7. Kaoru Sakatani
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  8. Misao Kawara
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Correspondence to Takashi Iida.

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Iida, T., Sakayanagi, M., Svensson, P. et al. Influence of periodontal afferent inputs for human cerebral blood oxygenation during jaw movements. Exp Brain Res 216, 375–384 (2012). https://doi.org/10.1007/s00221-011-2941-3

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  • DOI: https://doi.org/10.1007/s00221-011-2941-3

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