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Neuroanatomical identification of crossmodal auditory inputs to interneurons in somatosensory cortex

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Abstract

Multisensory convergence is the first, requisite step in the process that generates neural responses to events involving more than one sensory modality. Although anatomical studies have documented the merging of afferents from different sensory modalities within a given area, they do not provide insight into the architecture of connectivity at the neuronal level that underlies multisensory processing. In fact, few anatomical studies of multisensory convergence at the neuronal level have been conducted. The present study used a combination of tract-tracing, immunocytochemistry, and confocal microscopic techniques to examine the connections related to crossmodal auditory cortical inputs to somatosensory area SIV. Axons labeled from auditory cortex were found in contact with immunolabeled interneurons in SIV, some of which also colocalized vesicular glutamate transporter 1, indicating the presence of an active, glutamatergic synapse. No specific subtype of inhibitory interneuron appeared to be targeted by the crossmodal contacts. These results provide insight into the structural basis for multisensory processing at the neuronal level and offer anatomical evidence for the direct involvement of inhibitory interneurons in multisensory processing.

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Acknowledgments

This work was supported by NIH-NINDS Center Core Grant to VCU Anatomy and Neurobiology Microscopy Facility and NIH Grant NS39460 (to MAM).

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Authors and Affiliations

  1. Department of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, VA, 23298, USA

    Leslie P. Keniston, Scott C. Henderson & M. Alex Meredith

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  1. Leslie P. Keniston
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  2. Scott C. Henderson
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  3. M. Alex Meredith
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Correspondence to Leslie P. Keniston.

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Keniston, L.P., Henderson, S.C. & Meredith, M.A. Neuroanatomical identification of crossmodal auditory inputs to interneurons in somatosensory cortex. Exp Brain Res 202, 725–731 (2010). https://doi.org/10.1007/s00221-010-2163-0

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  • DOI: https://doi.org/10.1007/s00221-010-2163-0

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