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The impact of restricted diet on brain function using BOLD-fMRI

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Abstract

We investigated the effect of a restricted diet model on activity in the human motor cortex using functional magnetic resonance imaging (fMRI). Two series of blood oxygenation level-dependent (BOLD)-fMRI measurements were made in healthy subjects performing simple motor tasks using their right hands. The first series was done 5–10 days prior to the restricted diet schedule (controls), and the second series was performed after 25–28 days of restricted diet, in the form of a religious fast (Ramadan). The size and intensity of the activated area in the motor cortex increased during the time of restricted diet versus the controls. We conclude that restricted diet has a significant effect on cerebral activity, as shown by BOLD-fMRI, although the exact relationship between the images and neuronal activity due to the restricted diet is still to be determined.

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References

  • Belliveau JW, Kennedy DN, McKinstry RC, Buchbinder BR, Weisskoff RM, Cohen MS, Vevea JM, Brady TJ, Rosen BR (1991) Functional mapping of the human visual cortex by magnetic resonance imaging. Science 254:716–719

    Article  PubMed  CAS  Google Scholar 

  • Blamire AM, Ogawa S, Ugurbil K, Rothman D, McCarthy G, Ellermann JM, Hyder F, Rattner Z, Shulman RG (1992) Dynamic mapping of the human visual cortex by high-speed magnetic resonance imaging. Proc Natl Acad Sci USA 89:11069–11073

    Article  PubMed  CAS  Google Scholar 

  • Britsch PM, Grodd W, Klose U, Ackermann H (1996) Functional mapping of the motor system during voluntary movements with whole brain multislice EPI. Proc ISMRM 4:1865

    Google Scholar 

  • Buxton RB, Wong EC, Frank LR (1998) Dynamics of blood flow and oxygenation changes during brain activation: the balloon model. Magn Reson Med 39:855–864

    Article  PubMed  CAS  Google Scholar 

  • Disbrow E, Buonocore M, Antognini J, Carstens E, Rowley H (1998) Somatosensory cortex: a comparison of the response to noxious thermal, mechanical, and electrical stimuli using functional magnetic resonance imaging. Hum Brain Map 6:150–159

    Article  CAS  Google Scholar 

  • Frahm J, Dechent P, Baudewig J, Merboldt KD (2004) Advances in functional MRI of the human brain. Prog Nucl Mag Reson Spectro 44:1–32

    Article  CAS  Google Scholar 

  • Friston KJ, Holmes AP, Worsley KJ, Poline JP, Frith CD, Frackowiak RSJ (1995) Statistical parametric maps in functional imaging: a general linear approach. Hum Brain Map 2:189–210

    Article  Google Scholar 

  • Gati JS, Menon RS, Ugurbil K, Rutt BK (1997) Experimental determination of the BOLD field strength dependence in vessels and tissue. Magn Reson Med 38:296–302

    Article  PubMed  CAS  Google Scholar 

  • Haacke EM, Lai S, Reichenbach JR, Kuppusamy K, Hoogenraad FGC, Takeichi H, Lin WL (1997) In vivo measurement of blood oxygen saturation using magnetic resonance imaging: a direct validation of the blood oxygen level-dependent concept in functional brain imaging. Hum Brain Map 5:341–346

    Article  Google Scholar 

  • Kennedy JM, Zochodne DW (2005) Experimental diabetic neuropathy with spontaneous recovery. Is there irreparable damage? Diabetes 54:830–837

    CAS  Google Scholar 

  • Kim SG, Ashe J, Georgopoulos AP, Merkle H, Ellermann JM, Menon RS, Ogawa S, Ugurbil K (1993) Functional imaging of human motor cortex at high magnetic field. J Neurophysiol 69:297–302

    PubMed  CAS  Google Scholar 

  • Kollias SS, Valavanis A, Golay X, Boesiger P, McKinnon GC (1996) Functional magnetic resonance imaging of cortical activation. Int J Neuroradiol 2:450–472

    Google Scholar 

  • Kwong KK, Belliveau JW, Chesler DA, Goldberg IE, Weisskoff RM, Poncelet BP, Kennedy DN, Hoppel BE, Cohen MS, Turner R et al (1992) Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. Proc Natl Acad Sci USA 89:5675–5679

    Article  PubMed  CAS  Google Scholar 

  • Larijani B, Zahedi F, Sanjari M, Amini MR, Jalili RB, Adibi H, Vassigh AR (2003) The effect of Ramadan fasting on fasting serum glucose in healthy adults. Med J Malaysia 58:678

    PubMed  CAS  Google Scholar 

  • Mattson MP, Chan SL, Duan W (2002) Modification of brain aging and neurodegenerative disorders by genes, diet, and behavior. Physiol Rev 82:637–672

    PubMed  CAS  Google Scholar 

  • Mattson MP, Duan W, Guo Z (2003) Meal size and frequency affect neuronal plasticity and vulnerability to disease: cellular and molecular mechanisms. J Neurochem 84:417–431

    Article  PubMed  CAS  Google Scholar 

  • McGrath-Hanna NK, Greene DM, Tavernier RJ, Bult-Ito A (2003) Diet and mental health in the arctic: is diet an important risk factor for mental health in circumpolar people? Int J Circumpolar Health 62:228–241

    PubMed  Google Scholar 

  • Ogawa S, Lee T, Nayak AS, Glynn P (1990) Oxygenation sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields. Magn Reson Med 14:68–78

    Article  PubMed  CAS  Google Scholar 

  • Ogawa S, Tank DW, Menon R, Ellermann JM, Kim SG, Merkle H, Ugurbil K (1992) Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging. Proc Natl Acad Sci USA 89:5951–5955

    Article  PubMed  CAS  Google Scholar 

  • Raichle ME (1994) Images of the mind: studies with modern imaging techniques. Ann Rev Psychol 45:333–356

    Article  CAS  Google Scholar 

  • Turner R, Le Bihan D, Moonen CT, Despres D, Frank J (1991) Echo-planar time course MRI of cat brain oxygenation changes. Magn Reson Med 22:159–166

    Article  PubMed  CAS  Google Scholar 

  • Turner R, Jezzard P, Wen H, Kwong KK, Le Bihan D, Zeffiro T, Balaban RS (1993) Functional mapping of the human visual cortex at 4 and 1.5 Tesla using deoxygenation contrast EPI. Magn Reson Med 29:277–279

    Article  PubMed  CAS  Google Scholar 

  • Wildgruber D, Erb M, Klose U, Grodd W (1997) Sequential activation of supplementary motor area and primary motor cortex during self-paced finger movement in human evaluated by functional MRI. Neurosci Lett 227:161–164

    Article  PubMed  CAS  Google Scholar 

  • Wildgruber D, Klose U, Grodd W, Erb M, Ackermann H (1996) Dorsolateral prefrontal activation during reversal of automated word orders. Proc ISMRM 4:1866

    Google Scholar 

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Correspondence to L. J. Garey.

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Boujraf, S., Benajiba, N., Belahsen, F. et al. The impact of restricted diet on brain function using BOLD-fMRI. Exp Brain Res 173, 318–321 (2006). https://doi.org/10.1007/s00221-006-0500-0

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  • DOI: https://doi.org/10.1007/s00221-006-0500-0

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