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Statin treatment and a disease-specific pattern of β-amyloid peptides in Alzheimer’s disease

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Abstract

According to the amyloid cascade hypothesis, sporadic Alzheimer’s disease (AD) is caused by the production and aggregation of β-amyloid (Aβ), and the production of Aβ has recently been linked to the metabolism of cholesterol. We have previously published clinical studies where the effect of statin treatment on Aβ production has been investigated. No effect on Aβ was found, which is in disagreement with cell and animal studies. In the present study we investigated the effect of statin treatment on a disease-specific pattern consisting of a C-terminally-truncated quintet of Aβ peptides. Nineteen patients with AD were treated with simvastatin for 12 months and the quintet of Aβ peptides were analysed in cerebrospinal fluid before and after treatment. Also included was a group of 15 untreated patients with AD. We found that the Aβ peptide pattern at baseline was in agreement with earlier findings; however, we did not find any change in the Aβ peptide pattern after statin treatment. We suggest that clinical studies with extended treatment periods are performed where higher dosages of statins are used. We also believe that the pleiotropic effects of statins should be investigated further in order to elucidate the connection between Alzheimer’s disease and statin treatment.

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Acknowledgements

This study has been supported by the Swedish Medical Research Council (projects # 12103,09946, 14981 and 14002); Alzheimerfonden, Lund, Sweden; Åhlèns Stiftelse, Stockholm, Sweden; Stohnes Stiftelse, Stockholm, Sweden; Pfannenstills Stiftelse, Sweden, Stiftelsen för Gamla Tjänarinnor, Stockholm, Sweden and BMBF Funded Competence Net Dementia, Germany. We are very grateful to Sabine Paul for skilful technical assistance.

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  1. Institute of Clinical Neuroscience, Section of Experimental Neurochemistry, Göteborg University, Neurolabb, SU/Mölndal, 43180, Mölndal, Sweden

    Kina Höglund & Kaj Blennow

  2. Institute of Clinical Neuroscience, Section of Psychiatry, Göteborg University, Sweden

    Steinar Syversen & Anders Wallin

  3. Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany

    Piotr Lewczuk & Jens Wiltfang

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  1. Kina Höglund
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Correspondence to Kina Höglund.

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Höglund, K., Syversen, S., Lewczuk, P. et al. Statin treatment and a disease-specific pattern of β-amyloid peptides in Alzheimer’s disease. Exp Brain Res 164, 205–214 (2005). https://doi.org/10.1007/s00221-005-2243-8

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