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Recent advances in optical aptasensor technology for amplification strategies in cancer diagnostics

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Abstract

Aptamers are chemically synthetic single-stranded DNA or RNA molecules selected by molecular evolution. They have been widely used as attractive tools in biosensing and bioimaging because they can bind to a large variety of targets with high sensitivity and high affinity and specificity. As recognition elements, aptamers contribute in particular to cancer diagnostics by recognizing different cancer biomarkers, while they can also facilitate ultrasensitive detection by further employing signal amplification elements. Optical techniques have been widely used for direct and real-time monitoring of cancer-related biomolecules and bioprocesses due to the high sensitivity, quick response, and simple operation, which has greatly benefited cancer diagnostics. In this review, we highlight recent advances in optical platform-based sensing strategies for cancer diagnostics aided by aptamers. Limitations and current challenges are also discussed.

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Funding

This work is supported by the National Natural Science Foundation of China (grant nos. 8150140715, 81503463, 81801792), the Natural Science Foundation of Jiangsu Province of China (grant no. BK20170389), and the Science and Technology Program of Suzhou (SS201867).

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  1. Xinyue Kou and Xujia Zhang contributed equally to this work.

Authors and Affiliations

  1. Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, 215163, Jiangsu, China

    Xinyue Kou & Chenyu Jiang

  2. Kangda College of Nanjing Medical University, Lianyungang, 222000, Jiangsu, China

    Xujia Zhang

  3. Department of Clinical Laboratory, Children’s Hospital of Soochow University, Suzhou, 215025, Jiangsu, China

    Xuejun Shao

  4. Jinan Guokeyigong Science and Technology Development Co., Ltd., Jinan, 250103, Shandong, China

    Chenyu Jiang

  5. School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, Jiangsu, China

    Limin Ning

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  1. Xinyue Kou
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  2. Xujia Zhang
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  3. Xuejun Shao
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  4. Chenyu Jiang
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Correspondence to Chenyu Jiang or Limin Ning.

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Kou, X., Zhang, X., Shao, X. et al. Recent advances in optical aptasensor technology for amplification strategies in cancer diagnostics. Anal Bioanal Chem 412, 6691–6705 (2020). https://doi.org/10.1007/s00216-020-02774-7

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  • DOI: https://doi.org/10.1007/s00216-020-02774-7

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