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Re-exploring the high-throughput potential of microextraction techniques, SPME and MEPS, as powerful strategies for medical diagnostic purposes. Innovative approaches, recent applications and future trends

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Abstract

The human population continues to grow exponentially in the fast developing and most populated countries, whereas in Western Europe it is getting older and older each year. This inevitably raises the demand for better and more efficient medical services without increasing the economic burden in the same proportion. To meet these requirements, improvement of medical diagnosis is certainly a key aspect to consider. Therefore, we need powerful analytical methodologies able to go deeper and further in the characterization of human metabolism and identification of disease biomarkers and endogenous molecules in body fluids and tissues. The ultimate goal is to have a reliable and early medical diagnosis, mitigating the disease complications as much as possible. Microextraction techniques (METs) represent a key step in these analytical methodologies by providing samples in the suitable volumes and purification levels necessary for the characterization of the target analytes. In this aspect, solid-phase microextraction (SPME) and, more recently, microextraction by packed sorbent (MEPS), are powerful sample preparation techniques, characterized by their reduced time of analysis, low solvent consumption, and broad application. Moreover, as miniaturized techniques, they can be easily automatized to have a high-throughput performance in the clinical environment. In this review, we explore some of the most interesting MEPS and SPME applications, focusing on recent trends and applications to medical diagnostic, particularly the in vivo and near real time applications.

METs as powerful strategies for medical diagnostic purposes

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Acknowledgments

The authors acknowledge the Portuguese Foundation for Science and Technology (FCT) through the Pluriannual base funding (Project PEst-OE/QUI/UI0674/2011) and MS Portuguese Network (REDE/1508/RNEM/2005) for their support.

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Authors and Affiliations

  1. CQM - Centro de Química da Madeira, Universidade da Madeira, Campus Universitário da Penteada, 9000-390, Funchal, Portugal

    Jorge Pereira, Catarina Luís Silva, Rosa Perestrelo, João Gonçalves, Vera Alves & José S. Câmara

  2. Centro de Ciências Exactas e da Engenharia da Universidade da Madeira, Campus Universitário da Penteada, 9000-390, Funchal, Portugal

    Jorge Pereira, Catarina Luís Silva, Rosa Perestrelo, João Gonçalves, Vera Alves & José S. Câmara

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  1. Jorge Pereira
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  2. Catarina Luís Silva
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  4. João Gonçalves
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Correspondence to José S. Câmara.

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Pereira, J., Silva, C.L., Perestrelo, R. et al. Re-exploring the high-throughput potential of microextraction techniques, SPME and MEPS, as powerful strategies for medical diagnostic purposes. Innovative approaches, recent applications and future trends. Anal Bioanal Chem 406, 2101–2122 (2014). https://doi.org/10.1007/s00216-013-7527-4

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  • DOI: https://doi.org/10.1007/s00216-013-7527-4

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