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Surface plasmon resonance imaging for nucleic acid detection

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Abstract

Surface plasmon resonance imaging (SPRI) is a powerful tool for simple, fast and cheap nucleic acid detection. Great efforts have been made during the last decade with the aim of developing even more sensitive and specific SPRI-based methods to be used for the direct detection of DNA and RNA. Here, after a description of the fundamentals of SPRI, the state of the art of recent platform and assay developments is presented, with special attention given to advances in SPRI signal enhancement procedures.

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Acknowledgments

We acknowledge support from MIUR (PRIN 20093N774P, FIRB RBPR05JH2P ITALNANONET RINAME RBAP114AMK).

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Correspondence to Giuseppe Spoto.

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Published in the special issue Analytical Science in Italy with guest editor Aldo Roda.

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D’Agata, R., Spoto, G. Surface plasmon resonance imaging for nucleic acid detection. Anal Bioanal Chem 405, 573–584 (2013). https://doi.org/10.1007/s00216-012-6563-9

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