Abstract
An LC–MS–MS-based procedure for determination in hair of 14 different drugs of abuse belonging to the classes cocaine, amphetamine-like compounds, opiates, and hallucinogens has been developed. A pressurized-liquid extraction procedure was used and proved useful for quantitative recovery of all the analytes tested. This procedure, in conjunction with a simple decontamination step, performed to avoid false-positive samples, enabled the detection of all the analytes with LOQ ranging from 1.8 to 16 pg mg−1 and accuracy varying from 85 to 111 %. The procedure was validated in accordance with the SOFT/AAFS guidelines and seems to be suitable for routine determination of the drugs tested in hair.
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Published in the special issue Analytical Science in Italy with guest editor Aldo Roda.
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Sergi, M., Napoletano, S., Montesano, C. et al. Pressurized-liquid extraction for determination of illicit drugs in hair by LC–MS–MS. Anal Bioanal Chem 405, 725–735 (2013). https://doi.org/10.1007/s00216-012-6072-x
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DOI: https://doi.org/10.1007/s00216-012-6072-x