Abstract
Lithium salts are still one of the most popular therapeutic approaches to the treatment of bipolar disorders, notwithstanding the introduction of more modern, less toxic drugs. Because of a narrow therapeutic range, lithium serum concentrations must be strictly monitored during the treatment to avoid life-threatening neurotoxicity. For this purpose, methods based on flame photometry or ion-selective electrodes are usually applied. The aim of the present work was to develop and validate a simple method for the determination of lithium in serum based on capillary zone electrophoresis with indirect detection. A validation of the method was carried out, including a comparison with an automated routine method based on ion-selective electrodes.
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Awarded a Poster Prize on the occasion of the 47th Annual Meeting of the International Association of Forensic Toxicologists (TIAFT 2009) held in Geneva from 23-27 August 2009.
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Pascali, J.P., Sorio, D., Bortolotti, F. et al. Rapid determination of lithium in serum samples by capillary electrophoresis. Anal Bioanal Chem 396, 2543–2546 (2010). https://doi.org/10.1007/s00216-010-3537-7
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DOI: https://doi.org/10.1007/s00216-010-3537-7